868286-79-7

Usage

Appearance

White solid

Structure

Benzene ring with two methyl groups (CH3) attached at positions 1 and 3
Trifluoromethyl group (CF3) attached at position 5
Two carboxylate groups (COO-) on opposite ends of the benzene ring

Aromaticity

Due to the benzene ring, the compound exhibits aromatic properties

Fluorination

Presence of the trifluoromethyl group (CF3) contributes to unique electronic and steric properties

Ester functionality

The carboxylate groups (COO-) provide ester-like reactivity and potential for further chemical modification

Organic synthesis

As a building block for the synthesis of other organic compounds

Pharmaceuticals

As a starting material for the production of pharmaceutical drugs

Materials science

In the development of new materials with specific properties
These properties and applications are based on the unique structure of 1,3-dimethyl 5-(trifluoromethyl)benzene-1,3-dicarboxylate, which combines aromaticity, fluorination, and ester functionality.

Upstream product

• 1448038-12-7 C₁₆H₂₃N₃O₄ 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1459-93-4 dimethyl Isophthalate 
• 944392-68-1 dimethyl 5-(pinacolboryl)isophthalate 
• 887144-97-0 Togni's reagent 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 51839-15-7 5-iodo-isophthalic acid dimethyl ester 

Relevant academic research and scientific papers

Trifluoromethylation of 1-aryl-3,3-diisopropyltriazenes

A new method for the trifluoromethylation of functionalized aromatic diisopropyltriazenes is described. In a facile two-step, one-pot synthesis, various functionalized trifluoromethyl-substituted arenes are accessible in mostly good yields by using methyl iodide as iodination agent and the trifluoromethylation system (trifluoromethyl)trimethylsilane/potassium fluoride/copper iodide. This concept could be expanded to perfluoroethylation as well as ethoxycarbonyldifluoromethylation reactions. Copyright

Highly selective trifluoromethylation of 1,3-disubstituted arenes through iridium-catalyzed arene borylation

The old one two: A sequential iridium-catalyzed borylation and copper-catalyzed trifluoromethylation of arenes is described (see scheme; Pin=pinacol). The reaction is conducted under mild reaction conditions and tolerates a variety of functional groups. T

A general strategy for the perfluoroalkylation of arenes and arylbromides by using arylboronate esters and [(phen)CuRF]

A versatile method for the synthesis of aryl perfluoroalkanes from arenes and aryl bromides is described. Substituted arenes or aryl bromides are converted in situ to an aryl boronate ester that readily undergoes perfluoroalkylation in air with [(phen)CuRF]. A broad range of aryl bromide substrates were perfluoroalkylated in good yield for the first time. [(phen)CuCF3] is now commercially available and has been prepared on 20g scale. Copyright

1,3,5-SUBSTITUTED PHENYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.