86847-78-1

Basic information

• Product Name: N-(5-Methylpyridin-2-yl)pivalaMide
• Synonyms: N-(5-Methylpyridin-2-yl)pivalaMide;5-Methyl-2-(2,2,2-trimethylacetamido)pyridine;2,2-dimethyl-N-(5-methylpyridin-2-yl)propanamide;2,2-Dimethyl-N-(5-Methyl-Pyridin-2-Yl)-Propionamide(WX619031)
• CAS NO: 86847-78-1
• Molecular Formula: C11H16N2O
• Molecular Weight: 192.25754
• Mol File: 86847-78-1.mol

Chemical Properties

• Appearance: /Solid
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(5-Methylpyridin-2-yl)pivalaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-Methylpyridin-2-yl)pivalaMide(86847-78-1)
• EPA Substance Registry System: N-(5-Methylpyridin-2-yl)pivalaMide(86847-78-1)

Safety Data

• Hazardous Substances Data: 86847-78-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
N-(5-Methylpyridin-2-yl)pivalamide is utilized as a building block in organic synthesis, particularly in the pharmaceutical industry. Its unique structure allows it to be a key component in the creation of various biologically active molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-(5-Methylpyridin-2-yl)pivalamide serves as a reagent in the synthesis of pharmaceutical intermediates. These intermediates are essential for the development of new drugs, contributing to the advancement of medical treatments.
Used in Drug Development:
N-(5-Methylpyridin-2-yl)pivalaMide has potential applications in the development of new drugs due to its chemical properties. Researchers are exploring its capabilities in creating novel therapeutic agents that could address a range of health conditions.
Used in Agrochemical Development:
N-(5-Methylpyridin-2-yl)pivalamide also holds promise in the agrochemical sector. Its potential applications in this field are currently under investigation, with the aim of developing new products to enhance agricultural practices.
Ongoing Research and Development:
Due to its structural and chemical properties, N-(5-Methylpyridin-2-yl)pivalamide is the subject of ongoing research and development efforts. Scientists are continuously exploring its potential uses, seeking to unlock new possibilities in various industries.

Upstream product

• 171520-82-4 5-methyl-2-pivaloylaminopyridine N-oxide 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 850014-30-1 N-(3-bromo-5-methylpyridin-2-yl)pivaloylamide 
• 1083168-21-1 N-(6-(1-(2-cyanamido-2-oxoethyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-methylpyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide 
• 1083168-23-3 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)-5-methylpyridin-2-yl)cyclopropanecarboxamide 
• 1083168-52-8 1-(3-chloro-4-methoxyphenyl)-N-(6'-methoxy-3,5'-dimethyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 
• 1083168-53-9 1-(3-chloro-4-methoxyphenyl)-N-(5-methyl-6-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083168-50-6 C₂₃H₂₂ClN₃O₂ 
• 1083168-98-2 N-(6'-methoxy-3,5'-dimethyl-2,3'-bipyridin-6-yl)-1-(3-methoxyphenyl)cyclopropanecarboxamide 
• 1083168-58-4 1-(3-methoxyphenyl)-N-(5-methyl-6-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083168-51-7 1-(4-chlorophenyl)-N-(5-methyl-6-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 936727-56-9 N-(6-chloro-5-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide 
• 442129-37-5 6-amino-2-chloro-3-methylpyridine 
• 1023814-35-8 C₇H₈N₂O 
• 127446-31-5 2,2-Dimethyl-N-(3-formyl-5-methyl-2-pyridinyl)propanamide 
• 14759-22-9 3-methyl-[1,8]naphthyridine 

Relevant articles and documents

Rhodium(III)-catalyzed oxidative olefination of pyridines and quinolines: Multigram-scale synthesis of naphthyridinones

A Rh(III)-catalyzed oxidative olefination of pyridines and quinolines has been achieved. This method has a broad substrate scope and has been applied to the expeditious, multigram-scale synthesis of naphthyridinones.

An improved amide coupling procedure for the synthesis of N-(pyridin-2-yl)amides

Dehydrative amide couplings with 2-pyridylamines suffer from variable yields. A mild and high-yielding synthesis of N-(pyridin-2-yl)amides employing 2-aminopyridine-N-oxides is presented as a solution.

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.

7-Azaindoles via carbolithiation of vinyl pyridines

The sequential reactions of a pyridine vinylation and alkene carbolithiation constitutes a new route to substituted 7-azaindoles. The methodology involves a reaction sequence of controlled carbolithiation of the vinyl double bond, subsequent trapping of t

Regiospecific Electrophilic Substitution of Aminopyridines: Ortho Lithiation of 2-, 3-, and 4-(Pivaloylamino)pyridines

2- and 4-(pivaloylamino)pyridines have been shown to undergo metalation exclusively at C-3 and these smoothly react with a variety of electrophiles to produce 2,3- and 3,4-disubstituted pyridines, respectively.Removal of the pivaloyl protecting group results in overall electrophilic substitution of an aminopyridine.Utilization of this method is exemplified by efficient syntheses of 2- and 4-aminonicotinaldehydes.Minor modifications of the reaction conditions permitted exclusive ortho metalation of 2-(pivaloylamino)pyridines additionally functionalized by chloro, fluoro, or methyl groups.Although the major product from reaction of 3-(pivaloylamino)pyridine by this method was metalation at C-4, the reaction was complicated by substantial quantities of product derived from nucleophilic attack by n-butyllithium on the pyridine nucleus.