86847-78-1

Basic information

• Product Name: N-(5-Methylpyridin-2-yl)pivalaMide
• Synonyms: N-(5-Methylpyridin-2-yl)pivalaMide;5-Methyl-2-(2,2,2-trimethylacetamido)pyridine;2,2-dimethyl-N-(5-methylpyridin-2-yl)propanamide;2,2-Dimethyl-N-(5-Methyl-Pyridin-2-Yl)-Propionamide(WX619031)
• CAS NO: 86847-78-1
• Molecular Formula: C11H16N2O
• Molecular Weight: 192.25754
• Mol File: 86847-78-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /Solid
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(5-Methylpyridin-2-yl)pivalaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-Methylpyridin-2-yl)pivalaMide(86847-78-1)
• EPA Substance Registry System: N-(5-Methylpyridin-2-yl)pivalaMide(86847-78-1)

Safety Data

• Hazardous Substances Data: 86847-78-1(Hazardous Substances Data)

Usage

General Description

N-(5-Methylpyridin-2-yl)pivalaMide is a chemical compound with the formula C12H16N2O. It is a pivaloylamine derivative with a pyridine ring substituted with a methyl group. N-(5-Methylpyridin-2-yl)pivalaMide is used as a building block in organic synthesis, especially in the pharmaceutical industry. It can be used as a reagent in the synthesis of various biologically active molecules and pharmaceutical intermediates. Additionally, N-(5-Methylpyridin-2-yl)pivalaMide has potential applications in the development of new drugs and agrochemicals. Due to its structural and chemical properties, this compound is the subject of ongoing research and development efforts.

Upstream product

• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 3282-30-2 pivaloyl chloride 
• 171520-82-4 5-methyl-2-pivaloylaminopyridine N-oxide 

Downstream Products

• 1083168-21-1 N-(6-(1-(2-cyanamido-2-oxoethyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-methylpyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide 
• 1083168-23-3 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)-5-methylpyridin-2-yl)cyclopropanecarboxamide 
• 1083168-52-8 1-(3-chloro-4-methoxyphenyl)-N-(6'-methoxy-3,5'-dimethyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 
• 1083168-53-9 1-(3-chloro-4-methoxyphenyl)-N-(5-methyl-6-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083168-50-6 C₂₃H₂₂ClN₃O₂ 
• 1083168-98-2 N-(6'-methoxy-3,5'-dimethyl-2,3'-bipyridin-6-yl)-1-(3-methoxyphenyl)cyclopropanecarboxamide 
• 1083168-58-4 1-(3-methoxyphenyl)-N-(5-methyl-6-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083168-51-7 1-(4-chlorophenyl)-N-(5-methyl-6-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 936727-56-9 N-(6-chloro-5-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide 
• 442129-37-5 6-amino-2-chloro-3-methylpyridine 
• 1023814-35-8 C₇H₈N₂O 
• 850014-30-1 N-(3-bromo-5-methylpyridin-2-yl)pivaloylamide 
• 14759-22-9 3-methyl-[1,8]naphthyridine 
• 127446-31-5 2,2-Dimethyl-N-(3-formyl-5-methyl-2-pyridinyl)propanamide 

Relevant articles and documents

Rhodium(III)-catalyzed oxidative olefination of pyridines and quinolines: Multigram-scale synthesis of naphthyridinones

A Rh(III)-catalyzed oxidative olefination of pyridines and quinolines has been achieved. This method has a broad substrate scope and has been applied to the expeditious, multigram-scale synthesis of naphthyridinones.

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.

Regiospecific Electrophilic Substitution of Aminopyridines: Ortho Lithiation of 2-, 3-, and 4-(Pivaloylamino)pyridines

2- and 4-(pivaloylamino)pyridines have been shown to undergo metalation exclusively at C-3 and these smoothly react with a variety of electrophiles to produce 2,3- and 3,4-disubstituted pyridines, respectively.Removal of the pivaloyl protecting group results in overall electrophilic substitution of an aminopyridine.Utilization of this method is exemplified by efficient syntheses of 2- and 4-aminonicotinaldehydes.Minor modifications of the reaction conditions permitted exclusive ortho metalation of 2-(pivaloylamino)pyridines additionally functionalized by chloro, fluoro, or methyl groups.Although the major product from reaction of 3-(pivaloylamino)pyridine by this method was metalation at C-4, the reaction was complicated by substantial quantities of product derived from nucleophilic attack by n-butyllithium on the pyridine nucleus.