86851-23-2Relevant academic research and scientific papers
Enantioselective Nucleophilic β-Carbon-Atom Amination of Enals: Carbene-Catalyzed Formal [3+2] Reactions
Wu, Xingxing,Liu, Bin,Zhang, Yuexia,Jeret, Martin,Wang, Honglin,Zheng, Pengcheng,Yang, Song,Song, Bao -An,Chi, Yonggui Robin
, p. 12280 - 12284 (2016)
An enantioselective β-carbon amination for enals is disclosed. The nitrogen atom from a protected hydrazine with suitable electronic properties readily behaves as a nucleophile. Addition of the nitrogen nucleophile to a catalytically generated N-heterocyclic-carbene-bound α,β-unsaturated acyl azolium intermediate constructs a new carbon–nitrogen bond asymmetrically. The pyrazolidinone products from our catalytic reactions are common scaffolds in bioactive molecules, and can be easily transformed into useful compounds such as β3-amino-acid derivatives.
