868540-08-3

Usage

Uses

Used in Pharmaceutical Industry:
C₂₈H₃₆ClN₃O₅ is used as a medication for [specific medical condition or purpose] due to its [pharmacological properties or mechanism of action].
Used in Antimicrobial Applications:
In the field of microbiology, C₂₈H₃₆ClN₃O₅ is used as an antimicrobial agent for [specific application or target microorganisms], leveraging its chlorine atom's potential antimicrobial properties.

Upstream product

• 15136-32-0 (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 868539-96-2 (S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate 
• 79-04-9 chloroacetyl chloride 
• 868539-99-5 C₂HF₃O₂*C₂₆H₃₅N₃O₄ 

Downstream Products

• 1140908-89-9 C₃₂H₄₄N₄O₆ 
• 868540-16-3 (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid 
• 868540-17-4 carfilzomib 
• 868540-09-4 C₃₀H₄₂N₄O₅ 
• 868540-12-9 C₃₃H₄₆N₄O₅ 

Relevant academic research and scientific papers

CRYSTALLINE PEPTIDE EPOXY KETONE PROTEASE INHIBITORS AND THE SYNTHESIS OF AMINO ACID KETO-EPOXIDES

The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.

Compounds for enzyme inhibition

Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.