86863-93-6Relevant articles and documents
A flow microreactor system enables organolithium reactions without protecting alkoxycarbonyl groups
Nagaki, Aiichiro,Kim, Heejin,Moriwaki, Yuya,Matsuo, Chika,Yoshida, Jun-Ichi
supporting information; experimental part, p. 11167 - 11177 (2010/11/04)
A flow microreactor system consisting of micromixers and microtube reactors provides an effective tool for the generation and reactions of aryllithiums bearing an alkoxycarbonyl group at para-, meta-, and ortho-positions. Alkyl p- and m-lithiobenzoates were generated by the I/Li exchange reaction with PhLi. The Br/Li exchange reactions with sBuLi were unsuccessful. Subsequent reactions of the resulting aryllithiums with electrophiles gave the desired products in good yields. On the other hand, alkyl o-lithiobenzoates were successfully generated by the Br/ Li exchange reaction with sBuLi. Subsequent reactions with electrophiles gave the desired products in good yields.
Diels-Alder reactions of 1,3-cyclohexadienes and 3-(trimethylsilyl)propynoates. A new synthesis of ortho-(trimethylsilyl)benzoate esters
Kleschick, William A.,Thornburgh, Scott
, p. 1793 - 1799 (2007/10/03)
Diels-Alder reaction of 1,3-cyclohexadienes and 3-(trimethylsilyl)propynoates yields ortho-(trimethylsilyl)benzoates.
In Situ Trapping of Ortho-Lithiated Benzenes Containing Electrophilic Directing Groups
Krizan, Timothy D.,Martin, J. C.
, p. 6155 - 6157 (2007/10/02)
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