868632-44-4

Upstream product

• 536-74-3 phenylacetylene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 59046-72-9 o-(phenylethynyl)benzaldehyde 
• 62-53-3 aniline 

Downstream Products

• 809274-70-2 4-iodo-2,3-diphenyl-2H-isoquinolin-1-one 
• 520-03-6 N-phenylphthalimide 
• 14959-62-7 2-phenyl-3-phenylisoquinolin-1-one 
• 1186207-73-7 methyl 2-(4-bromophenyl)-2-(1,2-dihydro-2,3-diphenylisoquinolin-1-yl)-2-hydroxyacetate 
• 1186207-71-5 methyl 2-(3-bromophenyl)-2-(1,2-dihydro-2,3-diphenylisoquinolin-1-yl)-2-hydroxyacetate 
• 1186207-72-6 methyl 2-(3-chlorophenyl)-2-(1,2-dihydro-2,3-diphenylisoquinolin-1-yl)-2-hydroxyacetate 
• 1186207-70-4 methyl 2-(1,2-dihydro-2,3-diphenylisoquinolin-1-yl)-2-hydroxy-2-p-tolylacetate 
• 1186207-88-4 2-(1,2-dihydro-2,3-diphenylisoquinolin-1-yl)-2-hydroxy-1-phenylethanone 
• 1186207-69-1 methyl 2-(1,2-dihydro-2,3-diphenylisoquinolin-1-yl)-2-hydroxy-2-(4-methoxyphenyl)acetate 
• 1186207-68-0 methyl 2-(1,2-dihydro-2,3-diphenylisoquinolin-1-yl)-2-hydroxy-2-phenylacetate 
• 1186207-84-0 ethyl 2-tert-butoxy-2-(1,2-dihydro-2,3-diphenylisoquinolin-1-yl)acetate 
• 1186207-85-1 ethyl 2-(benzyloxy)-2-(1,2-dihydro-2,3-diphenylisoquinolin-1-yl)acetate 

Relevant academic research and scientific papers

Highly selective construction of medium-sized lactams by palladium-catalyzed intramolecular hydroaminocarbonylation of aminoalkynes

A novel palladium-catalyzed intramolecular hydroaminocarbonylation of aminoalkynes has been developed. This direct and operationally simple protocol provides a rapid and reliable approach to a diverse array of valuable seven-and eight-membered lactams with high chemoselectivity and regioselectivity. The high selectivity might be attributed to rational tuning the electronic nature of the amine moiety and the palladium catalyst which enabled this transformation to proceed in the absence of acidic or any other additives under fairly mild reaction conditions. This method paves the way for the synthesis of medium-sized lactams.

Regioselective synthesis of functionalized dihydroisoquinolines from: O -alkynylarylaldimines via the Reformatsky reaction

A novel approach for the synthesis of functionalized 1,2-dihydroisoquinolines from o-alkynylarylaldimines via the Reformatsky reaction without the aid of an external Lewis acid has been described. The chemistry involves the dual role of the Reformatsky reagent which has been generated in situ in the reaction. We propose that one molecule of the Reformatsky reagent is being utilised for the activation of alkynes, whereas the second molecule acts as a nucleophile on the iminium carbon. This synthetic pathway has high functional group tolerance, and can be utilized on a gram scale. The proposed mechanistic pathway is well supported by the control experiments. The 1,2-dihydroisoquinoline derivatives showed up to 90% inhibition of the strand transfer activity of the HIV integrase enzyme.