868944-69-8

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 1993-03-9 o-fluorophenylboronic acid 
• 346656-39-1 2-(2-fluorophenyl)-5,5-dimethyl-[1,3,2]dioxaborinane 

Downstream Products

• 1213704-83-6 2-(2-fluorophenyl)-6-phenylnicotinonitrile 
• 1213704-85-8 4-benzoyl-2-(2-fluorophenyl)nicotinonitrile 
• 1213704-82-5 6-tert-butyl-2-(2-fluorophenyl)nicotinonitrile 
• 34016-27-8 5-methylbenzo[h]-1,6-naphthyridine 
• 1213704-80-3 2-(2-fluorophenyl)-6-methylnicotinonitrile 
• 1213704-93-8 2-(3-cyanopyridin-2-yl)-3-fluorophenyl acetate 
• 1213704-87-0 2-(2-fluorophenyl)-4-(methylsulfanyl)nicotinonitrile 
• 1213704-86-9 2-(2-fluorophenyl)-4-trimethylsilanylnicotinonitrile 
• 1213704-81-4 6-butyl-2-(2-fluorophenyl)nicotinonitrile 
• 1169826-23-6 2-(2-fluoro-6-methoxyphenyl)nicotinonitrile 
• 1213704-94-9 5-bromo-2-(2-fluorophenyl)nicotinonitrile 
• 1213704-92-7 2-(2-bromo-6-fluorophenyl)nicotinonitrile 
• 1213704-91-6 2-(2-chloro-6-fluorophenyl)nicotinonitrile 
• 1213704-84-7 2-(2-fluorophenyl)-4-iodonicotinonitrile 

Relevant academic research and scientific papers

A new, direct, and efficient synthesis of benzonaphthyridin-5-ones

Microwave-assisted Suzuki cross-coupling reaction of 2-fluorophenylboronic acid with all orthochlorocyanopyridine isomers allowed the rapid syntheses of key intermediates for anionic ring closure, which was performed using potassium hydroxide under microwave irradiation to give benzonaphthyridin-5-ones in high yields.

AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE

A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R 5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

Synthesis of azaphenanthridines via anionic ring closure

A new and convergent synthesis of azaphenanthridines via an anionic ring closure is reported. Ortho-lithiation/in situ borylation of cyanopyridines produces the corresponding cyanopyridylboronic esters, which undergo a Suzuki-Miyaura cross-coupling to giv