869112-31-2

Basic information

• Product Name: Umeclidinium Bromide Impurity 4
• Synonyms: Umeclidinium Bromide Impurity 4;Umeclidinium Impurity 4
• CAS NO: 869112-31-2
• Molecular Formula: C22H28BrNO2
• Molecular Weight: 418.38
• Mol File: 869112-31-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Umeclidinium Bromide Impurity 4(CAS DataBase Reference)
• NIST Chemistry Reference: Umeclidinium Bromide Impurity 4(869112-31-2)
• EPA Substance Registry System: Umeclidinium Bromide Impurity 4(869112-31-2)

Safety Data

• Hazardous Substances Data: 869112-31-2(Hazardous Substances Data)

Usage

Uses

As the specific chemical structure and properties of Umeclidinium Bromide Impurity 4 are not readily available, it is not possible to list its uses based on the provided materials. However, it is important to monitor and control the levels of impurities in pharmaceutical products to ensure the quality and safety of the medications for patient use.

Upstream product

• 22766-68-3 azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester 
• 1126-09-6 4-carbethoxypiperidine 
• 939900-20-6 C₁₀H₁₉NO₃ 
• 869112-14-1 1-(2-chloroethyl)-4-piperidinecarboxylic acid ethyl ester 
• 461648-39-5 α,α-diphenyl-1-azabicyclo[2.2.2]octane-4-methanol 
• 540-51-2 2-bromoethanol 

Relevant articles and documents

Quinuclidine derivative, method for preparing same and application of quinuclidine derivative

The invention relates to a quinuclidine derivative, a pharmaceutically acceptable salt, pro-drug and solvent compound of the quinuclidine derivative, a method for preparing the quinuclidine derivative, a drug composition with the quinuclidine derivative and the pharmaceutically acceptable salt, pro-drug and solvent compound and pharmaceutical application of the quinuclidine derivative. The quinuclidine derivative, the pharmaceutically acceptable salt, pro-drug and solvent compound, the method, the drug composition and the pharmaceutical application have the advantage that the compound is excellent in M3 receptor antagonist activity and accordingly can be used as a novel efficient drug for chronic obstructive pulmonary diseases.

Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists

A novel 4-hydroxyl(diphenyl)methyl substituted quinuclidine series was discovered as a very promising class of muscarinic antagonists. The structure-activity relationships of the connectivity of the diphenyl moiety to the quinuclidine core and around the ring nitrogen side chain are described. Computational docking studies using an homology model of the M3 receptor readily explained the observed structure-activity relationship of the various compounds. Compound 14o was identified as a very potent, slowly reversible M3 antagonist with a very long in vivo duration of bronchoprotection.

Muscarinic acetylcholine receptor antagonists

Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.