869113-79-1Relevant academic research and scientific papers
Regio-controlled synthesis of N-substituted imidazoles
Xi, Ning,Xu, Shimin,Cheng, Yuan,Tasker, Andrew S.,Hungate, Randall W.,Reider, Paul J.
, p. 7315 - 7319 (2007/10/03)
A regio-specific synthesis of N-substituted imidazoles is described. Readily available α-amino acids are converted to α-aminocarbonyl derivatives and reacted with various isothiocyanates to give N-substituted cyclic thioureas. Oxidative or reductive desulfurization of the cyclic thioureas affords structurally diversified imidazoles in good to excellent yields.
