869301-36-0Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: New disease-modifying agents for Alzheimer's disease
Mu?oz-Ruiz, Pilar,Rubio, Laura,García-Palomero, Esther,Dorronsoro, Isabel,Del Monte-Millán, María,Valenzuela, Rita,Usán, Paola,De Austria, Celia,Bartolini, Manuela,Andrisano, Vincenza,Bidon-Chanal, Axel,Orozco, Modesto,Javier Luque,Medina, Miguel,Martínez, Ana
, p. 7223 - 7233 (2005)
New dual binding site acetylcholinesterase (AChE) inhibitors have been designed and synthesized as new potent drugs that may simultaneously alleviate cognitive deficits and behave as disease-modifying agents by inhibiting the β-amyloid (Aβ) peptide aggreg
TACRINE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE
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Page/Page column 18; 39, (2008/06/13)
The invention provides compounds of formula: (I) which have a tacrine moiety connected to an heterocyclic moiety through a linker. Through careful selection of the substituents and the linker, the activity and selectivity towards acetylcholinesterase can
Butyrylcholinesterase selective inhibitors
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Page/Page column 10, (2008/06/13)
The invention provides butyrylcholinesterase inhibitors of Formula I which contain an heterocyclic moiety and a 4 piperidine moiety with a linker in between. The compounds show a very high activity and selectivity towards BuChE, making them useful for the
