869310-65-6

Upstream product

• 124700-41-0 2-fluoro-5-iodobenzoic acid 
• 622-08-2 2-Benzyloxyethanol 
• 1251931-75-5 ethyl 3-(ethylamino)-2-[(2-fluoro-5-iodophenyl)carbonyl]-2-propenoate 
• 797041-75-9 1-ethyl-6-iodo-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 697762-43-9 ethyl 3-(dimethylamino)-2-[(2-fluoro-5-iodophenyl)carbonyl]-2-propenoate 
• 186584-73-6 2-fluoro-5-iodobenzoyl chloride 
• 219716-49-1 ({[2-(2-propyn-1-yloxy)ethyl]oxy}methyl)benzene 
• 797052-44-9 1-ethyl-6-iodo-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid 

Downstream Products

• 1251931-78-8 1-ethyl-4-oxo-6-[3-({2-[(phenylmethyl)oxy]ethyl}oxy)propyl]-1,4-dihydro-3-quinolinecarboxylic acid 
• 1251931-77-7 C₁₅H₁₇NO₃ 

Relevant academic research and scientific papers

Initial Scale-Up and Process Improvements for the Preparation of a Lead Antibacterial Macrolone Compound

Macrolones are a novel class of potent antimicrobial agents that consist of a macrolide scaffold to which a quinolone unit is tethered by various linkers to the 4 -O-position of the cladinose sugar. In this paper is described a modified 13-step route to a

Synthesis and biological activity of 4″-O-acyl derivatives of 14- and 15-membered macrolides linked to ω-quinolone-carboxylic unit

The synthesis and antimicrobial activity of a new class of macrolide antibiotics which consist of a macrolide scaffold and a quinolone unit covalently connected by an appropriate linker are described. Optimization of several synthetic steps and structural

MACROLONE COMPOUNDS

A compound of formula (I) compositions comprising same, processes for their preparation and use of said compounds, particularly in the treatment of microbial infections.

ESTER LINKED MACROLIDES USEFUL FOR THE TREATMENT OF MICROBIAL INFECTIONS

The present invention relates to 14- or 15-membered macrolides substituted at the 4” position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or top