869355-04-4Relevant articles and documents
Efficient synthesis of protected 3′-deoxyadenosine and 3′-deoxyguanosine from adenosine and guanosine
Cui, Zhiyong,Zhang, Lei,Zhang, Biliang
, p. 561 - 563 (2007/10/03)
Highly efficient synthesis of protected 3′-deoxyadenosine and 3′-deoxyguanosine from adenosine and guanosine were described. The 2′,3′-diol of protected adenosine and guanosine were reacted with α-acetoxyisobutyryl bromide to yield 9-(2′-O-acetyl-3′-bromo
Inhibition of 5-α-reductase (type-II) expression by antisense 3'- deoxy-(2'-5') oligonucleotide chimeras
Bhan, Purshotam,Bhan, Anila,Hong, Mikung,Hartwell, John G.,Saunders, June M.,Hoke, GlennD
, p. 1195 - 1199 (2007/10/03)
3'-Deoxy-(2'-5') oligonucleotides bind selectively to complementary RNA but not to DNA. 3'-Deoxy-(2'-5') phosphorothioate ODN chimeras embedded with a short stretch of 3'-5' phosphorothioate cassette are potent inhibitors of steroid 5-α-reductase expression with significantly less non-specific interactions in cell culture.
