86941-36-8Relevant articles and documents
INHIBITORS OF JANUS KINASES
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Page/Page column 123, (2009/01/23)
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
Asymmetric α-substituted phenethylamines. II. The enantioselective synthesis of 1-aryl-2-phenylethylamines from L- and D-amino acids by means of 1,3-asymmetric induction
Suzuki,Takahashi
, p. 31 - 40 (2007/10/02)
Optically pure (1S, 1'S)-1-aryl-N-(1'-alkyl-2'-hydroxyethyl)-2-phenylethylamines were synthesized from L-alanine, L-leucine, and L-isoleucine via (S)-2-aminoalkanols and (E)-(S)-N-(1-alkyl-2-hydroxyethyl)arylmethylideneamines. On the other hand, the amine