869501-11-1

Basic information

• Product Name: 1H-Imidazole-1-carboxylic acid, 4-[(4-hydroxycyclohexyl)methyl]-, 1,1-dimethylethyl ester
• CAS NO: 869501-11-1
• Molecular Formula: C15H24N2O3
• Molecular Weight: 280.367
• Mol File: 869501-11-1.mol

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-1-carboxylic acid, 4-[(4-hydroxycyclohexyl)methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-1-carboxylic acid, 4-[(4-hydroxycyclohexyl)methyl]-, 1,1-dimethylethyl ester(869501-11-1)
• EPA Substance Registry System: 1H-Imidazole-1-carboxylic acid, 4-[(4-hydroxycyclohexyl)methyl]-, 1,1-dimethylethyl ester(869501-11-1)

Safety Data

• Hazardous Substances Data: 869501-11-1(Hazardous Substances Data)

Upstream product

• 869501-10-0 4-(4-oxocyclohexylmethyl)imidazole-1-carboxylic acid tert-butyl ester 
• 317338-52-6 4-(1H-imidazol-5-ylmethyl)cyclohexanone 
• 317338-50-4 5-(1,4-dioxaspiro[4.5]dec-8-ylmethyl)-1H-imidazole 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 51656-91-8 ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate 
• 62141-26-8 ethyl 1,4-dioxaspiro[4.5]dec-8-ylacetate 
• 135761-76-1 2-(1,4-dioxaspiro[4.5]decan-8-yl)ethanol 
• 143948-97-4 8-formylethyl-1,4-dioxaspiro<4.5>decane 

Relevant articles and documents

New high affinity H3 receptor agonists without a basic side chain

In this study, we replaced the basic amine function of the known histamine H3 receptor agonists imbutamine or immepip with non-basic alcohol or hydrocarbon moieties. All compounds in this study show a moderate to high affinity for the cloned human H3 receptor and, unexpectedly, almost all of them act as potent agonists. Moreover, in the alcohol series, we consistently observed an increased selectivity for the human H3 receptor over the human H4 receptor, but none of the compounds in this series possess increased affinity and functional activity compared to their alkylamine congeners. In this new series of compounds VUF5657, 5-(1H-imidazol-4-yl)-pentan-1-ol, is the most potent histamine H3 receptor agonist (pKi = 8.0 and pEC50 = 8.1) with a 320-fold selectivity at the human H3 receptor over the human H 4 receptor.