869527-82-2Relevant academic research and scientific papers
INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES
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, (2021/12/28)
Provided herein are heteroaryl inhibitors of fibroblast growth factor receptor kinases, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.
Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences
Bueno, Ana B.,Agejas, Javier,Broughton, Howard,Dally, Robert,Durham, Timothy B.,Espinosa, Juan Félix,González, Rosario,Hahn, Patric J.,Marcos, Alicia,Rodríguez, Ramón,Sanz, Gema,Soriano, José F.,Timm, David,Vidal, Paloma,Yang, Hsiu-Chiung,McCarthy, James R.
, p. 9807 - 9820 (2017/12/26)
NMR conformational analysis of a hydroxyethylamine peptide isostere developed as an aspartic protease inhibitor shows that it is a flexible architecture. Cyclization to form pyrrolidines, piperidines, or morpholines results in a preorganization of the who
Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands
Ghosh, Arun K.,Takayama, Jun,Kassekert, Luke A.,Ella-Menye, Jean-Rene,Yashchuk, Sofiya,Agniswamy, Johnson,Wang, Yuan-Fang,Aoki, Manabu,Amano, Masayuki,Weber, Irene T.,Mitsuya, Hiroaki
, p. 4903 - 4909 (2015/10/28)
We describe the design, synthesis and biological evaluation of a series of novel HIV-1 protease inhibitors bearing isophthalamide derivatives as the P2-P3 ligands. We have investigated a range of acyclic and heterocyclic amides as the extended P2-P3 ligan
COMPOUNDS CONTAINING FUSED RINGS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
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, (2011/11/01)
The invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
BACE INHIBITORS
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Page/Page column 52-53, (2008/06/13)
The present invention provides BACE inhibitors of Formula (I): methods for their use and preparation, and intermediates for their preparation.
