86971-83-7Relevant academic research and scientific papers
Synthesis and neuroprotective action of xyloketal derivatives in Parkinson's disease models
Li, Shichang,Shen, Cunzhou,Guo, Wenyuan,Zhang, Xuefei,Liu, Shixin,Liang, Fengyin,Xu, Zhongliang,Pei, Zhong,Song, Huacan,Qiu, Liqin,Lin, Yongcheng,Pang, Jiyan
, p. 5159 - 5189 (2014/02/14)
Parkinson's disease (PD) is the second most common neurodegenerative disease affecting people over age 55. Oxidative stress actively participates in the dopaminergic (DA) neuron degeneration of PD. Xyloketals are a series of natural compounds from marine mangrove fungus strain No. 2508 that have been reported to protect against neurotoxicity through their antioxidant properties. However, their protection versus 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity is only modest, and appropriate structural modifications are necessary to discover better candidates for treating PD. In this work, we designed and synthesized 39 novel xyloketal derivatives (1-39) in addition to the previously reported compound, xyloketal B. The neuroprotective activities of all 40 compounds were evaluated in vivo via respiratory burst assays and longevity-extending assays. During the zebrafish respiratory burst assay, compounds 1, 9, 23, 24, 36 and 39 strongly attenuated reactive oxygen species (ROS) generation at 50 μM. In the Caenorhabditis elegans longevity-extending assay, compounds 1, 8, 15, 16 and 36 significantly extended the survival rates (p +). In the MPP+-induced C57BL/6 mouse PD model, 40 mg/kg of 1 and 8 protected against MPP+-induced dopaminergic neurodegeneration and increased the number of DA neurons from 53% for the MPP+ group to 78% and 74%, respectively (p 0.001 vs. MPP+ group). Thus, these derivatives are novel candidates for the treatment of PD.
The reaction of 3,4-dihydro-2H-pyran with oxalyl chloride: Formation and crystal structure analysis of an unexpected bicyclic product
Schmidt, Bernd,Werner, Frank,Kelling, Alexandra,Schildeb, Uwe
experimental part, p. 1171 - 1175 (2010/11/16)
(Chemical Equation Presented) 3,4-Dihydro-2-H-pyran and oxalyl chloride react, depending on the conditions, to keto esters, a pyran-3-carboxylic acid or derivatives thereof, or to an hitherto unknown bicyclic acetal containing a vinyl chloride moiety. The structure of the latter product has been unambiguously elucidated by single-crystal X-ray structure analysis. A mechanism for its formation is proposed.
A New Indirect Application of Aggregative Activation: Synthesis of Esters by Cobalt-Catalyzed Carbonylation of Aryl, Heterocyclic, and Vinyl Halides under Atmospheric Pressure
Marchal, Joel,Bodiguel, Jacques,Fort, Yves,Caubere, Paul
, p. 8336 - 8340 (2007/10/02)
Sun lamp illuminated alkoxycarbonylation of aryl, heteroaryl, and vinyl halides was performed under atmospheric pressure of CO in the presence of a cobalt catalyst in situ generated from Co(OAc)2.Illunination through a Pyrex flask was sufficient to catalyze the reaction.This process avoids the use of Co2(CO)8 and excess CH3I, which were required in the earlier procedure.A SRN1 mechanism is proposed.
Haloacetylated Enol Ethers: 4. Synthesis of 4-Trihalomethyl-2-methylthiopyrimidines
Madruga, Claudia da C.,Clerici, Edflia,Martins, Marcos A. P.,Zanatta, Nilo
, p. 735 - 738 (2007/10/02)
The synthesis of a series of 5- and 6-substituted 4-trihalomethyl-2-methylthiopyrimidines, prepared from the cyclocondensation reaction of β-alkoxyvinyl trichloromethyl ketones with 2-methyl-2-thiopseudourea sulfate, are reported.A systematic study to find the best reation conditions werre carried out.
