869788-71-6

Usage

Uses

Used in Pharmaceutical Industry:
Ursonic acid benzyl ester is used as a pharmaceutical agent for its potential anti-inflammatory and anti-cancer effects. Its ability to modulate inflammatory responses and inhibit cancer cell growth makes it a promising candidate for the development of new therapeutics.
Used in Antiviral Applications:
In the field of antiviral research, Ursonic acid benzyl ester is utilized as a potential antiviral agent, given its capacity to interfere with viral replication and infection processes, thereby offering a new approach to combat viral diseases.
Used in Hepatoprotective Therapy:
Ursonic acid benzyl ester is employed as a hepatoprotective agent, aimed at improving liver function and reducing liver fibrosis. Its demonstrated efficacy in experimental studies positions it as a potential treatment for liver-related conditions.
Used in Drug Development:
In the drug development sector, Ursonic acid benzyl ester is used as a lead compound for the creation of novel medications. Its multifaceted medicinal properties suggest that it could be a valuable component in the formulation of new drugs targeting various diseases and conditions.

Upstream product

• 77-52-1 ursolic acid 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 94482-51-6 ursonic acid 
• 192211-41-9 benzyl (1S,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,-11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate 

Downstream Products

• 869788-72-7 (1S,2R,4aS,6aS,6bR,8aR,12aR,12bR,14bS)-10-Acetoxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,12,12a,12b,13,14b-hexadecahydro-2H-picene-4a-carboxylic acid benzyl ester 
• 958237-68-8 benzyl-2-hydroxy-3-oxours-1,12-dien-28-oic acid 
• 958237-69-9 benzyl-2α-hydroxy-3-oxours-12-en-28-oic acid 
• 869788-73-8 benzyl-2α,3β-dihydroxyurs-12-en-28-oic acid 
• 4547-24-4 corosolic acid 
• 1034619-13-0 benzyl-3α-hydroxyurs-12-en-28-oic acid 
• 1415383-29-7 (4aS,6aS,6bR,12aR)-benzyl 11-cyano-1,2,6a,6b,9,9,12a-heptamethyl-10-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate 
• 1415383-30-0 (4aS,6aS,6bR,13aR)-benzyl 12-amino-1,2,6a,6b,9,9,13a-heptamethyl-2,3,4,4a,5,6,6a,6b,7,8,8a,9,11,13,13a,13b,14,15b-octadecahydro-1H-chryseno[1,2-f]indazole-4a-carboxylate 

Relevant academic research and scientific papers

Ursolic amide derivative containing pyrazole heterocycle, and synthesis and application thereof

The present invention provides the structure general formula of a class of pyrazole heterocycle-containing ursolic amide derivatives, further a synthesis route and synthesis steps of the pyrazole heterocycle-containing ursolic amide derivatives, and uses

Low-toxicity anti-inflammatory ursolic acid derivative as well as preparation method and application thereof

The invention belongs to the technical field of pentacyclic triterpene compounds and application thereof, and particularly relates to a low-toxicity and anti-inflammatory ursolic acid derivative as well as a preparation method and application thereof. Acc

An Ursolic Acid Derived Small Molecule Triggers Cancer Cell Death through Hyperstimulation of Macropinocytosis

Macropinocytosis is a transient endocytosis that internalizes extracellular fluid and particles into vacuoles. Recent studies suggest that hyperstimulation of macropinocytosis can induce a novel nonapoptotic cell death, methuosis. In this report, we descr

Ursolic acid derivative containing parazole heterocycle as well as synthesis and application thereof

The invention provides a general structural formula of an ursolic acid derivative containing a parazole heterocycle. The invention further provides a synthetic route of the ursolic acid derivative containing the parazole heterocycle and synthesis steps of

Pentacyclic triterpene derivatives possessing polyhydroxyl ring A inhibit Gram-positive bacteria growth by regulating metabolism and virulence genes expression

The hydroxyl group in ring A of pentacyclic triterpene is essential for antibacterial activity. Pentacyclic triterpenes bearing three hydroxyl groups in ring A were mainly found in plants and displayed significant antibacterial activity. However, no study

FUSED TRITERPENE COMPOUNDS AND USES THEREOF

The present invention discloses fused triterpene compounds, represented by the compounds of Formula I (as described herein), processes for their preparation, pharmaceutical compositions comprising the said compounds, their use as retinoid-related orphan receptors gamma (RORγ) modulators and/or interleukin-17 (IL-17) inhibitors and methods for their use in the treatment of a disease or a disorder mediated by RORγ and/or IL-17.

Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties

The scalable syntheses of four oxygenated triterpenes have been implemented to access substantial quantities of maslinic acid, 3-epi-maslinic acid, corosolic acid, and 3-epi-corosolic acid. Semi-syntheses proceed starting from the natural products oleanolic acid and ursolic acid. Proceeding over five steps, each of the four compounds can be synthesized on the gram scale. Divergent diastereoselective reductions of α-hydroxy ketones provided access to the four targeted diol containing compounds from two precursors of the oleanane or ursane lineage. These compounds were subsequently evaluated for their ability to inhibit inflammatory gene expression in a mouse model of chemically induced skin inflammation. All compounds possessed the ability to inhibit the expression of one or more inflammatory genes induced by 12-O-tetradecanoylphorbol-13 acetate in mouse skin, however, three of the compounds, corosolic acid, 3-epi-corosolic acid and maslinic acid were more effective than the others. The availability of gram quantities will allow further testing of these compounds for potential anti-inflammatory activities as well as cancer chemopreventive activity.

Novel inhibitors of bacterial biofilms and related methods

Multi-cyclic compounds of chemical structure represented by formula given below and compositions thereof are useful for reducing or inhibiting the growth of bacterial biofilms and for controlling bacterial biofilm infections. Such compounds and compositions are also useful in methods for reducing or inhibiting the growth of biofilms and for controlling bacterial biofilm infections involving biofilms.

MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 betulinic acid and other structurally related natural products derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.

C-28 AMIDES OF MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 and C-28 betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.