869788-93-2Relevant academic research and scientific papers
Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase
Song, Suhee,Lee, Hyojin,Jin, Youngeup,Ha, Young Mi,Bae, Sungjin,Chung, Hae Young,Suh, Hongsuk
, p. 461 - 464 (2007)
Oxyresveratrol and resveratrol, with hydroxy substituted trans-stilbene structure, exert potent inhibitory effects on cyclooxygenase, rat liver mitochondrial ATPase activity, and tyrosinase. As the isosteres of oxyresveratrol, a new family of hydroxyl sub
A newly synthesized, potent tyrosinase inhibitor: 5-(6-Hydroxy-2-naphthyl)- 1,2,3-benzenetriol
Choi, Jehun,Bae, Sung Jin,Ha, Young Mi,No, Jae Kyung,Lee, Eun Kyeong,Lee, Jun Sik,Song, Suhee,Lee, Hyojin,Suh, Hongsuk,Yu, Byung Pal,Chung, Hae Young
, p. 4882 - 4884 (2010)
In searching for new agents with a depigmenting effect, we synthesized a derivative of resveratrol, 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol (5HNB) with a potent tyrosinase inhibitory activity. 5HNB inhibited mushroom tyrosinase with an IC50 value of 2.95 μM, which is more potent than the well-known anti-tyrosinase activity of kojic acid (IC50 = 38.24). The results of the enzymatic inhibition kinetics by Lineweaver-Burk analysis indicated 5HNB inhibits tyrosinase non-competitively when l-tyrosine was used as the substrate. Based on the strong inhibitory action of 5HNB, it is expected that 5HNB can suppress melanin production in which tyrosinase plays the essential role. Our expectation was confirmed by the experimentations with B16 melanoma cells in which 5HNB inhibited melanin production. We propose that 5HNB might have skin-whitening effects as well as therapeutic potential for treating skin pigmentation disorders.
Resorcinarene-mono-benzimidazolium salts as NHC ligands for Suzuki-Miyaura cross-couplings catalysts
I?ci, ümit,Aygün, Muhittin,Sevincek, Resul,Zorlu, Yunus,Dumoulin, Fabienne
, p. 1300 - 1309 (2016/03/01)
Two mono-benzimidazolium salts of resorcinarene have been prepared and used as ligands in Suzuki-Miyaura cross-coupling reactions. They have been fully characterized by 1H and 13C NMR, MALDI, and FT-IR spectroscopic methods, and their structures were confirmed by X-ray diffraction analysis. These two new resorcinarene-based mono-benzimidazolium salts showed good catalytic activity for coupling reactions in DMF. The highest conversion was achieved for arylation of 4-bromotoluene using the resorcinarenyl mono-dimethylbenzimidazolium salt.
Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells
Roberti, Marinella,Pizzirani, Daniela,Recanatini, Maurizio,Simoni, Daniele,Grimaudo, Stefania,Di Cristina, Antonietta,Abbadessa, Vincenzo,Gebbia, Nicola,Tolomeo, Manlio
, p. 3012 - 3018 (2007/10/03)
To further explore the SAR of resveratrol-related trans-stilbene derivatives, here we describe the synthesis of (a) a series of 3,5-dimethoxy analogues in which a variety of substituents were introduced at positions 2′, 3′, 4′, and 5′ of the stilbene scaf
Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells
Minutolo, Filippo,Sala, Giusy,Bagnacani, Annalisa,Bertini, Simone,Carboni, Isabella,Placanica, Giorgio,Prota, Giovanni,Rapposelli, Simona,Sacchi, Nicoletta,Macchia, Marco,Ghidoni, Riccardo
, p. 6783 - 6786 (2007/10/03)
Resveratrol, a natural product with a stilbene structure, exerts profound proapoptotic activity in human cancer cells, by triggering the accumulation of ceramide, a bioactive sphingolipid. We studied the biological effects of seven methoxylated and/or nap
