86981-92-2Relevant academic research and scientific papers
Iridium-catalyzed asymmetric hydrogenation of α-substituted α,β-unsaturated acyclic ketones: Enantioselective total synthesis of (-)-mesembrine
Zhang, Qian-Qian,Xie, Jian-Hua,Yang, Xiao-Hui,Xie, Jian-Bo,Zhou, Qi-Lin
supporting information, p. 6158 - 6161 (2013/02/23)
A highly efficient asymmetric hydrogenation of α-substituted α,β-unsaturated acyclic ketones catalyzed by chiral spiro iridium complexes for the preparation of chiral 2-substituted allylic alcohols has been developed (ee up to 99.7%). This method provides a concise route to (-)-mesembrine (34% yield, 12 steps).
Using nazarov electrocyclization to stage chemoselective [1,2]-migrations: Stereoselective synthesis of functionalized cyclopentenones
Lebuf, David,Huang, Jie,Gandon, Vincent,Frontier, Alison J.
supporting information; experimental part, p. 10981 - 10985 (2011/12/16)
Highly functionalized cyclopentenones have been prepared stereospecifically through a chemoselective copper(II)-mediated Nazarov/Wagner-Meerwein rearrangement sequence. After the initial 4π electrocyclization, this reaction involves two sequential [1,2]-m
A CONVENIENT ROUTE TO α,β-UNSATURATED METHYL KETONES APPLICATION TO RETINAL ANALOGUE SYNTHESIS
Croteau, Allan A.,Termini, John
, p. 2481 - 2484 (2007/10/02)
Deprotonated ketimines 1a,b add to aldehydes and ketones to provide tri- and tetra-substituted α,β-unsaturated methyl ketones 2a,b with substantial percentage of Z-geometry which are not readily accessible by other methods.
