869884-00-4Relevant articles and documents
Preparation method for (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
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, (2019/03/31)
The invention relates to a medical intermediate, in particular to a preparation method for (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline. Benzoyl chloride or benzoic acid, phenylethylamine, alkali metalhydroxide and water are mixed to react, N-(2-phenethyl)benzamide, phosphorus pentoxide and phosphorus chloride at a certain ratio are mixed and heated with organic solvent, obtained 1-phenyl-3,4-dihydroisoquinoline, a first alcohol solvent and borohydride are mixed to react, the obtained 1-phenyl-1,2,3,4-dihydroisoquinoline, a second alcohol solvent, water and D-tartaric acid are mixed and heatedto react, the obtained (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline tartrate, alkali metal hydroxide and water are mixed to obtain a target product. The preparation method for (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline has the advantages of simpleness in operation and aftertreatment.
1-phenyl -1, 2, 3, 4-isoquinoline method for the preparation of
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, (2017/01/26)
The invention provides a 1-phenyl-1, 2, 3, 4-tetrahydroisoquinoline preparation method. The 1-phenyl-1, 2, 3, 4-tetrahydroisoquinoline preparation method comprises the following steps of: mixing benzoyl chloride or benzoic acid, phenethylamine and alkali metal hydroxide with water, and reacting to obtain N-(2-phenethyl) benzamide; then mixing the N-(2-phenethyl) benzamide with phosphorus pentoxide, chloride phosphorus and a benzene solvent, heating and reacting to obtain 1-phenyl-3, 4-dihydro-isoquinoline; and further mixing the 1-phenyl-3, 4-dihydro-isoquinoline with a first alcohol solvent and hydroboron, and reacting to obtain the product. Compared with the prior art, the 1-phenyl-1, 2, 3, 4-tetrahydroisoquinoline preparation method has the advantages that firstly, no organic solvents are added, the product N-(2-phenethyl) benzamide is insoluble in an aqueous solution, and therefore, the steps of skimming and the like are avoided in the after-treatment process, and the after-treatment operation is simplified; secondarily, as the organic solvents are not added, the cost is reduced, and the pollution to environments is avoided; and thirdly, as the phosphorus pentoxide and the chloride phosphorus are subjected to oxidization cyclization reaction, polyphosphoric acids are prevented from being heated and decomposed to generate hypertoxic phosphorus oxide exhaust gas.
Processes for optical resolution of 1-phenyl-1,2,3,4-tetrahydroisoquinoline
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Page/Page column 5, (2010/11/30)
Optically pure 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline tartrate is prepared. The 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline tartrate is particularly useful for preparing solifenacin succinate.