869964-34-1Relevant articles and documents
Total synthesis and biological evaluation of pederin, psymberin, and highly potent analogs
Wan, Shuangyi,Wu, Fanghui,Rech, Jason C.,Green, Michael E.,Balachandran, Raghavan,Horne, W. Seth,Day, Billy W.,Floreancig, Paul E.
, p. 16668 - 16679 (2011)
The potent cytotoxins pederin and psymberin have been prepared through concise synthetic routes (10 and 14 steps in the longest linear sequences, respectively) that proceed via a late-stage multicomponent approach to construct the N-acyl aminal linkages.
PEDERIN AND PSYMBERIN AGENTS
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Page/Page column 42-45, (2013/03/26)
Compounds that include a pederin, psymberin or pederin/psymberin chimera scaffold. The pederin scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The psymberin scaffold in
Concise and stereoselective synthesis of the N7-C25 fragment of psymberin
Rech, Jason C.,Floreancig, Paul E.
, p. 5175 - 5178 (2007/10/03)
(Chemical Equation Presented) The N7-C25 fragment of the potent and selective cytotoxic agent psymberin has been prepared through a short (12 linear steps, 15 total steps) and stereoselective sequence. Highlights of this route includ