869964-35-2Relevant academic research and scientific papers
PEDERIN AND PSYMBERIN AGENTS
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, (2013/03/26)
Compounds that include a pederin, psymberin or pederin/psymberin chimera scaffold. The pederin scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The psymberin scaffold in
Total synthesis and biological evaluation of pederin, psymberin, and highly potent analogs
Wan, Shuangyi,Wu, Fanghui,Rech, Jason C.,Green, Michael E.,Balachandran, Raghavan,Horne, W. Seth,Day, Billy W.,Floreancig, Paul E.
, p. 16668 - 16679 (2011/12/14)
The potent cytotoxins pederin and psymberin have been prepared through concise synthetic routes (10 and 14 steps in the longest linear sequences, respectively) that proceed via a late-stage multicomponent approach to construct the N-acyl aminal linkages.
Concise and stereoselective synthesis of the N7-C25 fragment of psymberin
Rech, Jason C.,Floreancig, Paul E.
, p. 5175 - 5178 (2007/10/03)
(Chemical Equation Presented) The N7-C25 fragment of the potent and selective cytotoxic agent psymberin has been prepared through a short (12 linear steps, 15 total steps) and stereoselective sequence. Highlights of this route includ
