87007-45-2

Upstream product

• 93134-36-2 5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-3'-O-levulinoyl-2'-deoxyadenosine 
• 3279-26-3 methyl dichlorophosphite 
• 80615-00-5 3'-O-formyl-N-benzoyl-2'-deoxyadenosine 
• 67219-55-0 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 
• 676-97-1 methylphosphonic acid dichloroanhydride 
• 85231-45-4 N-benzoyl-3'-O-levulinoyl-2'-deoxy-β-D-adenosine 

Downstream Products

• 87007-46-3 Phosphoric acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester (2R,3S,5R)-5-(6-amino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 

Relevant academic research and scientific papers

Improvements in Oligodeoxyribonucleotide Synthesis: Methyl N,N-Dialkylphosphoramidite Dimer Units for Solid Support Phosphite Methodology

Two procedures for the synthesis of methyl N,N-dialkylphosphoramidite dinucleotides (dimer units) compatible with the current solid support phosphite methodology of oligodeoxynucleotide synthesis are described for the first time.In the first procedure a c

SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES FROM 3'-O-FORMYL-(N-ACYL)-2'-DEOXYRIBONUCLEOSIDES USING o-CHLOROPHENYLPHOSPHODITRIAZOLIDE AND/OR METHYL PHOSPHODICHLORIDITE. REMOVAL OF METHYL GROUP FROM PHOSPHOTRIESTER BY THE ACTION OF AQUEOUS PYRIDINE

d-GGAATTCC (XI) was prepared by phosphomonotriazolide method in solution.Synthesis of oligodeoxyribonucleotides by phosphite method in solution using methyl phosphodichloridite was studied.Preparation of P-methyl esters of protected d-CA (XVII), d-CAT (XIX), d-TT (XXI) and d-ATT (XXIII) is described.The removal of methyl group from methyl containing phosphotriester by the action of aqueous pyridine is described.