383-29-9

Usage

Uses

Used in Chemical Synthesis:
4-Fluorophenyl sulfone is used as a synthetic intermediate for the production of various chemical compounds. Its reactivity in substitution reactions with deprotonated amines makes it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Fluorophenyl sulfone is utilized as a key component in the development of new drugs. Its unique chemical properties allow it to be incorporated into the molecular structures of potential therapeutic agents, contributing to their overall efficacy and selectivity.
Used in Material Science:
4-Fluorophenyl sulfone is also employed in the field of material science, where it is used to create novel materials with specific properties. Its ability to participate in substitution reactions enables the development of materials with tailored characteristics, such as improved stability, reactivity, or selectivity.

InChI:InChI=1/C9H6BrF3O/c10-5-8(14)6-1-3-7(4-2-6)9(11,12)13/h1-4H,5H2

Upstream product

• 462-06-6 fluorobenzene 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 404-38-6 4,4'-difluorodiphenyl sulfide 
• 395-25-5 bis(4-fluorophenyl)sulfoxide 
• 1156-50-9 4-nitrophenyl sulfone 
• 7790-94-5 chlorosulfonic acid 
• 368-88-7 4-fluorobenzenesulfonic acid 
• 80-09-1 4,4'-sulfonediphenol 
• 17763-90-5 4,4'-sulfonylbis(phenyltrifluoromethanesulfonate) 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 87014-32-2 Bis sulfone 
• 96308-23-5 C₁₄H₁₀F₄O₃S 
• 81943-93-3 di(pyridyloxy-3)-4,4' diphenylsulfone 
• 917868-79-2 4-fluoro-4'-(4''-methoxyphenyloxy)diphenyl sulfone 
• 34018-55-8 4,4'-(4'',4'''-dimethoxyphenyloxy)diphenyl sulfone 
• 1253665-88-1 3,3′,5,5′-tetraphenyl-4,4′-difluorodiphenyl sulfone 
• 79881-12-2 3,3'-dibromo-4,4'-difluorodiphenyl sulfone 
• 1253665-82-5 3,3'-diphenyl-4,4'-difluorodiphenyl sulfone 
• 1001416-41-6 4-(3,5-dimethoxyphenoxy)-4'-fluorodiphenylsulfone 
• 1403239-54-2 C₄₆H₃₈O₁₃S₂ 
• 1403239-50-8 4-(3,5-dihydroxyphenoxy)-4'-fluorodiphenylsulfone 
• 34922-35-5 bis[4-(diphenylamino)phenyl] sulfone 
• 1396165-17-5 bis{4-[bis(4-tert-butylphenyl)amine]phenyl} sulfone 
• 80-09-1 4,4'-sulfonediphenol 

Relevant academic research and scientific papers

Selective synthesis of sulfoxides and sulfonesviacontrollable oxidation of sulfides withN-fluorobenzenesulfonimide

A practical and mild method for the switchable synthesis of sulfoxides or sulfonesviaselective oxidation of sulfides using cheapN-fluorobenzenesulfonimide (NFSI) as the oxidant has been developed. These highly chemoselective transformations were simply achieved by varying the NFSI loading with H2O as the green solvent and oxygen source without any additives. The good functional group tolerance makes the strategy valuable.

Facile synthesis of diarylsulfones from arenes and 3CdSO4·xH2O via mechanochemistry

A variety of substituted diarylsulfones could be synthesized by simple arenes and 3CdSO4·xH2O in the presence of P2O5 under high-speed ball milling. It was suggest the aromatic sulfonation was performed by arene and in situ generated H2SO4, following-up by electrophilic substitution with another arene to give diarylsulfone.

One-pot fluorosulfurylation of Grignard reagents using sulfuryl fluoride

Herein, we report a new method for the one-pot syntheses of sulfonyl fluorides. Addition of an alkyl, aryl, or heteroaryl Grignard to a solution of sulfuryl fluoride at ambient temperature affords the desired sulfonyl fluorides in 18-78% yield. Furthermore, this method is applicable for in situ sequential reactions, whereby the Grignard reagent can be converted to the corresponding diarylsulfone, sulfonate ester, or sulfonamide in a one-pot process.

The synthesis of diarylsulfones with simple arenes and K2S2O8 through double C-S bond formation

An unprecedented double C-S bond formation method has been developed to prepare both symmetric and unsymmetric diarylsulfones with simple arenes in a single step. This represents the first example that K2S2O8 can be employed as a highly effective sulfonating agent to synthesize diarylsulfones. The reaction demonstrates excellent reactivity, good functional group tolerance and high yields.

Synthesis of symmetrical diaryl sulfone by homocoupling of sodium arylsulfinate

An efficient practical homocoupling reaction of sodium arylsulfinate promoted by Cu(II) is reported whereby symmetrical diaryl sulfone derivatives are obtained with high selectivity and reactivity by intermolecular cross-coupling. This homocoupling reacti

An improved catalyst system for the Pd-catalyzed fluorination of (hetero)aryl triflates

The stable Pd(0) species [(1,5-cyclooctadiene)(L·Pd)2] (L = AdBrettPhos) has been prepared and successfully evaluated as a precatalyst for the fluorination of aryl triflates derived from biologically active and heteroaryl phenols, challenging substrates for our previously reported catalyst system. Additionally, this precatalyst activates at room temperature under neutral conditions, generates 1,5-cyclooctadiene as the only byproduct, and leads to overall cleaner reaction profiles.

Pd-catalyzed desulfonylative homocoupling of arenesulfonyl chlorides in the presence of hexamethyldisilane forming biaryls

Arenesulfonyl chlorides undergo desulfonylative homo-coupling upon heating with hexamethyldisilane in the presence of Pd2(dibenzylideneacetone) 3?CHCl3 as a precatalyst to afford biaryls. Diaryl sulfides are occasionally formed as byproducts.

Indium(III)-catalysed aryl sulfonylation reactions

A rapid, high yielding and regioselective process has been developed for the synthesis of biaryl sulfones via sulfonylation reactions catalysed by indium(III) chloride.

Polymer electrolyte and process for producing the same

A polymer electrolyte having, in a main chain, a structural unit represented by the following formula (1):-[Ar1-(SO2-N-(X+)-SO2-Ar2)m-SO2-N-(X+)-SO2-Ar1-O]- wherein Ar1 and Ar2 independently represent a divalent aromatic groups, m represents an integer of 0 to 3, and X+ represents an ion selected from hydrogen ion, an alkali metal ion and ammonium ion, which is excellent in proton conductivity, thermal resistance and strength. The polymer electrolyte is soluble in solvents and has excellent film forming property and recycling efficiency.

Preparation process of fluorine substituted aromatic compound

A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylamino-difluoromethane compound, for example, 2,2′-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.