420-87-1

Usage

Uses

Used in Organic Synthesis:
Sodium 2,2,2-trifluoroethanolate is used as a reagent for its high reactivity in organic synthesis, facilitating the production of pharmaceuticals and agrochemicals. Its ability to engage in nucleophilic substitution and dehydration reactions makes it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, sodium 2,2,2-trifluoroethanolate is utilized as a reagent to aid in the synthesis of various drugs. Its reactivity and catalytic properties contribute to the development of new medicinal compounds.
Used in Agrochemical Production:
Similarly, in agrochemical production, sodium 2,2,2-trifluoroethanolate is employed as a reagent to synthesize a range of agrochemicals, such as pesticides and herbicides, due to its capacity to participate in key chemical reactions necessary for their creation.
Used as a Catalyst in Chemical Reactions:
Sodium 2,2,2-trifluoroethanolate is also used as a catalyst in certain chemical reactions, enhancing the efficiency and speed of these processes, which is particularly important in industrial applications where time and cost are critical factors.

InChI:InChI=1/C2H2F3O.Na/c3-2(4,5)1-6;/h1H2;/q-1;+1

Upstream product

• 855719-15-2 trifluoroethanol 
• 100-46-9 benzylamine 
• 75-89-8 2,2,2-trifluoroethanol 
• 7646-69-7 sodium hydride 

Downstream Products

• 70818-92-7 1.1-Dicyano-2-p-dimethylaminophenyl-2-trifluorethoxyethylen 
• 74010-49-4 (Z)-2-Acetylamino-3-phenyl-acrylic acid 2,2,2-trifluoro-ethyl ester 
• 80071-55-2 7,7,7-trifluoro-1-phenyl-5-oxa-2-thiaheptane 
• 87014-29-7 1-nitro-3-(2,2,2-trifluoroethoxy)benzene 
• 56935-77-4 ortho-2,2,2-trifluoroethoxy benzonitrile 
• 83190-03-8 2-chloro-4-nitro-1-(2,2,2-trifluoroethoxy)benzene 
• 84328-69-8 5-nitro-2-(2,2,2-trifluoroethoxy)benzonitrile 
• 135863-64-8 Phenyl-phosphorimidic acid tris-(2,2,2-trifluoro-ethyl) ester 
• 96308-27-9 2-(2,2,2-trifluoroethoxy)fluorobenzene 
• 84328-66-5 m-(2,2,2-Trifluoroethoxy)benzonitrile 
• 93624-57-8 2,6-di-2',2',2'-trifluoroethoxybenzonitrile 
• 35554-38-2 methyl 4-(2,2,2-trifluoroethoxy)-benzoate 
• 93624-59-0 3-chloro-6-2',2',2'-trifluoroethoxybenzonitrile 
• 87014-32-2 Bis sulfone 

Relevant academic research and scientific papers

Rate constants for hydrogen abstraction from alkoxides by a perfluoroalkyl radical. An oxyanion accelerated process

A combination of laser flash photolysis and competitive kinetic methods has been used to measure the absolute bimolecular rate constants for hydrogen atom abstraction in water from a series of fluorinated alkoxides and aldehyde hydrates by the perfluoroalkyl radical, CF2CF2OCF 2CF2SO3-Na+. The bimolecular rate constants observed for the β-fluorinated alkoxides were in the 105 M-1 s-1 range, such rates representing enhancements (relative to the respective alcohols) of between 100 and almost 1000-fold, depending on the reactivity of the alkoxide. Likewise, the monobasic sodium salts of chloral and fluoral hydrate exhibit similar rate enhancements, relative to their respective hydrates.

Brominated single walled carbon nanotubes as versatile precursors for covalent sidewall functionalization

Herein we report on the facile preparation of brominated SWCNTs based on two complementary reductive activation routes. The respective brominated SWCNTs are highly reactive and can be used in nucleophilic substitution reactions and represent versatile starting materials for the generation of sidewall functionalized SWCNTs with a high density of functional moieties. This journal is the Partner Organisations 2014.

BORON CONTAINING COMPOUNDS AND THEIR USES

The present disclosure contemplates novel boron-containing compounds and their uses as active agents that exhibit pesticidal activity such as antimicrobial, insecticidal, arachnicidal, and/or anti parasitic activity. An agrochemical composition containing such a compound and its use in, animal health, agriculture, or horticulture is also contemplated. A method for promoting plant performance and/or controlling, reducing, preventing, ameliorating, or inhibiting microbes, insects, arachnids, and/or parasites on or in an animal, a plant, a plant part, plant propagation material, and/or harvested fruits or vegetables is also contemplated.

Phosphazene-derived stable and robust artificial SEI for protecting lithium anodes of Li-O2batteries

A stable artificial solid electrolyte interphase (ASEI) containing phosphazene and perfluoroalkoxy groups was designed to protect Li anodes. The ASEI with high ionic conductivity and mechanicalrobustness successfully suppressed the growth of Li dendrites, significantly enhancing the electrochemical performance of the Li-O2 batteries.

Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold

Neutral sphingomyelinase 2 (nSMase2), a key enzyme in ceramide biosynthesis, is a new therapeutic target for the treatment of neurological disorders and cancer. Using 2,6-dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]phenol (DPTIP), our initial hit compound (IC50 = 30 nM) from nSMase2 screening efforts, as a molecular template, a series of 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol derivatives were designed, synthesized, and evaluated. Systematic examination of various regions of DPTIP identified the key pharmacophore required for potent nSMase2 inhibition as well as a number of compounds with the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold with similar or higher inhibitory potency against nSMase2 as compared to DPTIP. Among them, 4-(4,5-diisopropyl-1H-imidazol-2-yl)-2,6-dimethoxyphenol (25b) was found to be metabolically stable against P450 metabolism in liver microsomes and displayed higher plasma exposure following oral administration as compared to DPTIP. Analysis of plasma samples identified an O-glucuronide as the major metabolite. Blockade of the phase II metabolism should further facilitate our efforts to identify potent nSMase2 inhibitors with desirable ADME properties.

Compound having histone deacetylase-inhibiting activity, and pharmaceutical composition comprising the compound as an active ingredient

A novel compound having histone deacetylase-inhibiting activity which is a cyclic tetrapeptide derivative represented by the general formula (1) given below and a pharmaceutical composition comprising such compound as an active ingredient. (In the formula, the cyclic tetrapeptide moiety has a known structure; R1 and R2 each independently represents an alkylene group containing 1 to 6 carbon atoms, which may be branched; X represents a group or bond selected from among —CO—, —O—, —S— or —SO—; Y represents a hydrogen or halogen atom, a phenyl group (including a substituted form), a pyridyl group (including a substituted form), an alkyl group (including a halogen-substituted form; hereinafter the same shall apply) containing 1 to 6 carbon atoms, an alkyloxy group containing 1 to 6 carbon atoms, an alkylcarbonyl group containing 1 to 6 carbon atoms, an alkyloxycarbonyl group containing 1 to 6 carbon atoms, an alkylthio group containing 1 to 6 carbon atoms, an alkylthiocarbonyl group containing 1 to 6 carbon atoms or a mono- or dialkylamino group containing 1 to 6 carbon atoms; when Y is a phenyl group (including a substituted form) or a pyridyl group (including a substituted form), it may form a further cyclic structure bound to R2.)

PROCESS FOR THE PREPARATION OF 3- AND 4-(PENTAFLUOROSULFANYL)BENZENES

Process for the preparation of substituted 3- and 4-(pentafluorosulfanyI)benzenes of general formula 3 and 4 by nucleophilic aromatic substitution, where nitrobenzene having pentafiuorosulfanyl group connected in position 3 or 4 is allowed to react in concentration range 0.01 to 8.0 mol.l-1 with compound RY-M+, where R is selected from a group comprising saturated, unsaturated, acyclic, cyclic or aromatic, substituted or unsubstituted carbon chain, Y is the element of VI. B group and M+ is the metal ion, in an organic solvent. The invention includes also further chemical modifications of primary products.

DIHYDRO- 1H- PYRROLO [1,2-A] INDOL-1-YL CARBOXYLIC DERIVATIVES WHICH ACT AS S1P1 AGONISTS

The present invention relates to certain (1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl carboxylic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, sepsis, myocardial infarction, ischemic stroke, acne, microbial infections or diseases and viral infections or diseases.

INSECTICIDAL SUBSTITUTED AZINYL DERIVATIVES

N-Azinyl-N′-aryl ureas and thioureas derivatives are effective at controlling insects.

Isothiazole derivatives and processes for preparing the same as well as termite controlling agents comprising the same as active ingredient

Isothiazole derivatives represented by general formula (I): wherein R, R1, Y and Z have the same significances as described in the specification, and processes for preparing the same as well as termite controlling agents comprising the same as active ingredient, are disclosed.