870180-36-2

Upstream product

• 499195-27-6 Acetic acid (1S,2S,3R,5S,6R)-2-acetoxy-3,5-diazido-6-(4-methoxy-benzyloxy)-cyclohexyl ester 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 236115-61-0 [(1S,2S,3R,4S,6R)-2-acetoxy-4,6-diazido-3-hydroxy-cyclohexyl] acetate 
• 2037-48-1 2-deoxystreptamine 
• 90899-14-2 (1α,2β,3α,4β,6β)-4,6-Diazido-1,2,3-cyclohexantriol 
• 609342-79-2 2-deoxy-1,3-diazido-5,6-O-isopropylidenestreptamine 

Downstream Products

• 499195-37-8 ((1S,2R,3S,4S,5R)-3,4-Bis-benzyloxy-5-benzyloxycarbonylamino-2-hydroxy-cyclohexyl)-carbamic acid benzyl ester 
• 499195-41-4 ((1S,3R,4S,5R)-3,4-Bis-benzyloxy-5-benzyloxycarbonylamino-2-oxo-cyclohexyl)-carbamic acid benzyl ester 
• 499195-49-2 (3R,4R,6S)-3-Benzyloxy-4,6-bis-benzyloxycarbonylamino-cyclohex-1-enecarboxylic acid 
• 499195-45-8 ((1S,4R,5R)-4-Benzyloxy-5-benzyloxycarbonylamino-2-formyl-cyclohex-2-enyl)-carbamic acid benzyl ester 
• 499195-32-3 1,3-di-azido-5,6-di-O-benzyl-2-deoxystreptamine 

Relevant academic research and scientific papers

The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides

The first carbohydrate-free aminoglycoside analogs bearing the 2-deoxystreptamine moiety were synthesized from asymmetrically protected 2-deoxystrepamine and subsequently demonstrated to have significant binding to the 16S A-site rRNA target and moderate

Efficient Synthesis of Heterocyclic 2-Deoxysteptamine Derivatives as RNA Binding Ligands

An efficient strategy for the synthesis of heterocyclic 2-deoxystreptamine derivatives is described. The resulting compounds showed good RNA binding affinities from ESI-MS RNA binding assay.

Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA

The ribosomal decoding site is the target of aminoglycoside antibiotics that specifically recognize an internal loop RNA structure. We synthesized RNA-targeted 2,5-dideoxystreptamine-4-amides in which a sugar moiety in natural aminoglycosides is replaced by heterocycles.