870483-65-1Relevant articles and documents
Discovery of a 4-Azetidinyl-1-thiazoyl-cyclohexane CCR2 antagonist as a development candidate
Zhang, Xuqing,Hou, Cuifen,Hufnagel, Heather,Singer, Monica,Opas, Evan,McKenney, Sandra,Johnson, Dana,Sui, Zhihua
supporting information, p. 1039 - 1044 (2013/02/23)
We have discovered a novel series of 4-Azetidinyl-1-Aryl-cyclohexanes as CCR2 antagonists. Divergent SAR studies on hCCR2 and hERG activities led to the discovery of compound 8d, which displayed good hCCR2 binding affinity (IC 50, 37 nM) and po
3-(4-Heteroarylcyclohexylamino)cyclopentanecarboxamides as modulators of chemokine receptors
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Page/Page column 20, (2010/02/14)
The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or act