870537-93-2

Upstream product

• 511274-69-4 C-((2R,3R,4S,5R,6S)-4,5-Dimethoxy-3-pent-4-enyloxy-6-phenylsulfanyl-tetrahydro-pyran-2-yl)-methylamine 
• 39716-58-0 pent-4-enoyl chloride 
• 511274-40-1 (2R,3R,4S,5R,6S)-2-Hydroxymethyl-4,5-dimethoxy-6-phenylsulfanyl-tetrahydro-pyran-3-ol 
• 511274-68-3 (2R,3R,4S,5R,6S)-2-Azidomethyl-4,5-dimethoxy-3-pent-4-enyloxy-6-phenylsulfanyl-tetrahydro-pyran 
• 870537-88-5 Toluene-4-sulfonic acid (2R,3R,4S,5R,6S)-3-hydroxy-4,5-dimethoxy-6-phenylsulfanyl-tetrahydro-pyran-2-ylmethyl ester 
• 1119-51-3 bromopentene 
• 161391-28-2 phenyl 4,6-O-benzylidene-2,3-di-O-methyl-1-thio-β-D-glucopyranose 
• 511274-64-9 (2R,3R,4S,5R,6S)-2-Azidomethyl-4,5-dimethoxy-6-phenylsulfanyl-tetrahydro-pyran-3-ol 

Relevant academic research and scientific papers

A convergent ring-closing metathesis approach to carbohydrate-based macrolides with potential antibiotic activity

An efficient convergent approach has been developed for the construction of novel, non-natural, carbohydrate-based macrolides. The key step in the synthesis is the formation of the macrocyclic ring via a ring-closing metathesis reaction. The obtained macrolide analogues have been screened for biological activity against Gram-positive and Gram-negative bacteria, including resistant strains, yeasts, and molds.