87073-75-4

Basic information

• Product Name: 4-Chloro-2-dimethylaminobenzaldehyde
• Synonyms: 4-Chloro-2-dimethylaminobenzaldehyde
• CAS NO: 87073-75-4
• Molecular Weight: 183.637
• Mol File: 87073-75-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-Chloro-2-dimethylaminobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-dimethylaminobenzaldehyde(87073-75-4)
• EPA Substance Registry System: 4-Chloro-2-dimethylaminobenzaldehyde(87073-75-4)

Safety Data

• Hazardous Substances Data: 87073-75-4(Hazardous Substances Data)

Upstream product

• 61072-56-8 4-chloro-2-fluorobenzaldehyde 
• 506-59-2 N,N-dimethylammonium chloride 
• 71916-82-0 1-(bromomethyl)-4-chloro-2-fluorobenzene 
• 124-40-3 dimethyl amine 
• 452-75-5 4-chloro-2-fluorotoluene 
• 87066-92-0 (4-Chloro-2-dimethylamino-phenyl)-methanol 

Relevant articles and documents

Double Capture of Difluorocarbene by 2-Aminostyrenes Enables the Construction of 3-(2,2-Difluoroethyl)-2-fluoroindoles

We report herein an efficient strategy to construct 3-(2,2-difluoroethyl)-2-fluoroindoles from activated o-aminostyrenes with ethyl bromodi-fluoroacetate as a difluorocarbene source. Through double capture of a difluorocarbene, two different types of fluo

Enantioselective syntheses of no-carrier-added (n.c.a.) (S)-4-chloro-2-[18F] fluorophenylalanine and (S) - (α-methyl) -4-chloro-2-[18F]fluorophenylalanine

(S)-4-Chloro-2-fluorophenylalanine and (S)-(α-methyl)-4-chloro-2-fluorophenylalanine were synthesized and labeled with no carrier added (n.c.a.) fluorine-18 through a radiochemical synthesis relying on the highly enantioselective reaction between 4-chloro-2-[18F]fluorobenzyl iodide and the lithium enolate of (2S)-1-(tert-butyloxycarbonyl)-2-(tert-butyl)-3-methyl-1,3-imidazolidine-4-one for (S)-4-chloro-2-[18F]fluorophenylalanine and (2S,5S)-1-(tert-butyloxycarbonyl)-2-(tert-butyl)-3,5-dimethyl-1,3-imidazolidine-4-one for (S) - (α-methyl)-4-chloro-2-[18F] fluorophenylalanine. Quantities of about 20-25 mCi were obtained at the end of synthesis, ready for injection after hydrolysis and high performance liquid chromatography (HPLC) purification, with a radiochemical yield of 17%-20% corrected to the end of bombardment after a total synthesis time of 90-105 min from [18F]fluoride. The enantiomeric excesses were shown to be 97% or more for both molecules without chiral separation and the radiochemical and chemical purities were 98% or better.