87077-46-1

Basic information

• Product Name: 1-(4-ethyl-phenyl)-2-methyl-propan-2-ol
• Synonyms: 1-(4-ethyl-phenyl)-2-methyl-propan-2-ol
• CAS NO: 87077-46-1
• Molecular Weight: 178.274
• Mol File: 87077-46-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-(4-ethyl-phenyl)-2-methyl-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-ethyl-phenyl)-2-methyl-propan-2-ol(87077-46-1)
• EPA Substance Registry System: 1-(4-ethyl-phenyl)-2-methyl-propan-2-ol(87077-46-1)

Safety Data

• Hazardous Substances Data: 87077-46-1(Hazardous Substances Data)

Upstream product

• 96524-70-8 methyl 2-(4-formylphenyl)acetate 
• 155380-11-3 methyl 4-(hydroxymethyl)phenylacetate 
• 67634-15-5 4-ethyl-α,α-dimethyl-benzenepropanal 
• 75-16-1 methylmagnesium bromide 
• 75251-24-0 1-(4-ethylphenyl)propan-2-one 

Downstream Products

• 100248-66-6 1-ethyl-4-(β-chloro-isobutyl)-benzene 
• 101775-25-1 N-[2-(4-ethyl-phenyl)-1,1-dimethyl-ethyl]-acetamide 

Relevant articles and documents

Chemoselective Deoxygenation of 2° Benzylic Alcohols through a Sequence of Formylation and B(C6F5)3-Catalyzed Reduction

A sequence of formylation and B(C6F5)3-catalyzed reduction of the resulting formate with Et3SiH enables the chemoselective deoxygenation of secondary benzylic alcohols. Primary benzylic and tertiary non-benzylic alcohols are not reduced by this protocol. The formyl group fulfills a double role as activator and self-sacrificing protecting group. The deoxygenation of these formates is fast and can be carried out in the presence of other potentially reducible groups. Neighboring-group participation was found in the deoxygenation of certain diol motifs.

Use of 5-hydroxy-4H-benzo[1,4]oxazin-3-ones as β2-adrenoceptor agonists

Novel β2-agonists with a 5-hydroxy-4H-benzo[1,4]oxazin-3-one moiety as head group are described. Systematic chemical variations at the phenethylamine residue of these compounds lead to the discovery of compound 6m as potent, full agonist of the β2-adrenoceptor with a high β1/β2-selectivity. Molecular modeling revealed an interaction between the carboxylic acid group of 6m and a lysine residue (K305) of the β2-receptor as putative explanation for the high observed selectivity. Further, compound 6m displayed in a guinea pig in vivo model a complete reversal of acetylcholine induced bronchoconstriction which lasted over the complete study time of 5 h.

Aerosol formulation for the inhalation of beta-agonists

The present invention relates to a propellant-free aerosol formulation which [contains] one or more compounds of general formula 1 wherein the groups R1, R2, R3 and X? may have the meanings given in the claims a