87077-62-1

Basic information

• Product Name: 4-(2-chlorophenyl)-2-methylbutan-2-ol
• Synonyms: 4-(2-chlorophenyl)-2-methylbutan-2-ol
• CAS NO: 87077-62-1
• Molecular Weight: 198.692
• Mol File: 87077-62-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(2-chlorophenyl)-2-methylbutan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-chlorophenyl)-2-methylbutan-2-ol(87077-62-1)
• EPA Substance Registry System: 4-(2-chlorophenyl)-2-methylbutan-2-ol(87077-62-1)

Safety Data

• Hazardous Substances Data: 87077-62-1(Hazardous Substances Data)

Upstream product

• 74124-86-0 3-chlorophenylpropionic acid methyl ester 
• 74-88-4 methyl iodide 
• 1643-28-3 3-(2-chlorophenyl)propanoic acid 
• 91574-67-3 2-chlorobenzalacetone 
• 89-98-5 2-chloro-benzaldehyde 
• 3506-72-7 4-(2-chlorophenyl)-butan-2-one 
• 75-16-1 methylmagnesium bromide 

Relevant articles and documents

8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study

β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC50 2-agonists among the compounds tested. They behaved as partial β2-agonists in non-overexpressed HEK293 cells, and possessed rapid smooth muscle relaxant actions and long duration of action in isolated guinea pig tracheal strip preparations. In summary, B05 and C08 are β2-agonists with potential applicability in chronic respiratory diseases.