74124-86-0

Basic information

• Product Name: Methyl 3-(2-chlorophenyl)propanoate
• Synonyms: Methyl 3-(2-chlorophenyl)propanoate;Benzenepropanoic acid, 2-chloro-, Methyl ester
• CAS NO: 74124-86-0
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 199
• Mol File: 74124-86-0.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 3-(2-chlorophenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-(2-chlorophenyl)propanoate(74124-86-0)
• EPA Substance Registry System: Methyl 3-(2-chlorophenyl)propanoate(74124-86-0)

Safety Data

• Hazardous Substances Data: 74124-86-0(Hazardous Substances Data)

Usage

General Description

Methyl 3-(2-chlorophenyl)propanoate is a chemical compound with the molecular formula C11H13ClO2. It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. This chemical is a colorless to light yellow liquid with a slightly sweet odor and is soluble in organic solvents such as ethanol and ether. Methyl 3-(2-chlorophenyl)propanoate is known to be a potential irritant to the skin, eyes, and respiratory system, and should be handled with proper safety precautions. It is important to follow proper handling and storage procedures when using this chemical to ensure safety and prevent potential health hazards.

Upstream product

• 67-56-1 methanol 
• 1643-28-3 3-(2-chlorophenyl)propanoic acid 
• 98288-14-3 methyl (2E)-3-(2-chlorophenyl)prop-2-enoate 
• 186581-53-3 diazomethane 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 124-38-9 carbon dioxide 
• 2039-87-4 2-chlorostyrene 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 13524-04-4 2'-chloro-sec-phenethyl alcohol 
• 201230-82-2 carbon monoxide 
• 20001-46-1 1-chloro-2-(1-methoxyethyl)benzene 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 1170060-01-1 1-(3,4-dimethoxyphenyl)-2-[(2Z)-1,2,3,4-tetrahydroquinolin-2-ylidene]ethan-1-one 
• 119225-99-9 1-phenyl-2-((2Z)-1,2,3,4-tetrahydroquinolin-2-ylidene)ethan-1-one 
• 24118-66-9 5-(2-chlorophenyl)-1-phenylpentane-1,3-dione 
• 54877-27-9 1-chloro-2-(3-bromopropyl)benzene 
• 87077-62-1 4-(2-chlorophenyl)-2-methylbutan-2-ol 
• 6282-87-7 3-(2-chlorophenyl)-propanol 
• 1643-28-3 3-(2-chlorophenyl)propanoic acid 

Relevant articles and documents

Reduction of Electron-Deficient Alkenes Enabled by a Photoinduced Hydrogen Atom Transfer

Direct hydrogen atom transfer from a photoredox-generated Hantzsch ester radical cation to electron-deficient alkenes has enabled the development of an efficient formal hydrogenation under mild, operationally simple conditions. The HAT-driven mechanism is supported by experimental and computational studies. The reaction is applied to a variety of cinnamate derivatives and related structures, irrespective of the presence of electron-donating or electron-withdrawing substituents in the aromatic ring and with good functional group compatibility. (Figure presented.).

Palladium-Catalyzed Alkoxycarbonylation of sec-Benzylic Ethers

Herein, we report the palladium-catalyzed synthesis of 3-arylpropionate esters starting from secondary benzylic ethers. With this investigation it could be shown that ethers are suitable starting materials in addition to the established carbonylation reactions of olefins, alcohols, or aryl halides.

Synthesis of N-Substituted Condensed Tetrahydropyridine-Based Enaminones via Palladium-Catalyzed Intramolecular C–N Cross-coupling

A number of β-enaminones with secondary amino group (alkyl, cyclopropyl, and aryl) were prepared from corresponding β-diketones. Two general protocols for their palladium-catalyzed intramolecular C–N cross-coupling were established to give corresponding N-substituted condensed tetrahydropyridines in good yields. The methodology is applicable for a wide variety of structural motifs. The work also extends the applicability of novel, recently established, palladium precatalysts to new substrates.