87118-96-5

Usage

Purpose

Chiral derivatizing agent for the analysis of chiral alcohols and amines

Industries

Mainly used in pharmaceutical and chemical industries

Applications

Separation and analysis of enantiomers, synthesis of chiral building blocks and pharmaceutical intermediates, resolving agent in the resolution of racemic mixtures, chiral auxiliary in asymmetric synthesis, and production of agrochemicals and flavors and fragrances.

Explanation

1-Propanol, 2-(phenylmethoxy)-, methanesulfonate, (S)is a compound that is used to analyze chiral alcohols and amines. It is primarily used in the pharmaceutical and chemical industries for the separation and analysis of enantiomers. The compound is also important in the synthesis of other chiral compounds, such as building blocks and intermediates for pharmaceuticals. In addition, it is used as a resolving agent to separate racemic mixtures and as a chiral auxiliary in asymmetric synthesis. Furthermore, it has applications in the production of other products, such as agrochemicals and flavors and fragrances.

Upstream product

• 33106-64-8 (S)-2-(benzyloxy)propan-1-ol 
• 124-63-0 methanesulfonyl chloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 1443133-40-1 C₃₅H₃₉NO₄ 
• 33106-37-5 (2S)-2-benzyloxy-1-iodopropane 

Relevant academic research and scientific papers

COMPOUNDS FOR USE IN THE TREATMENT OR PROPHYLAXIS OF PAIN, INFLAMMATION AND/OR AUTOIMMUNITY

The present invention relates to a polymorphic form of (S,S)-2-N(3-O-(propan-2-ol)-1-propyl- 4-hydroxybenzene)-3-phenylpropylamide or synonymously named N-[2-(4-Hydroxy-phenyl)- -(2-hydroxy-propoxymethyl)-ethyl]-3-phenyl-propionamide and to the treatment

ISOLATED STEREOISOMERIC FORMS OF (S) 2-N (3-O-(PROPAN 2-OL) -1-PROPYL-4-HYDROXYBENZENE) -3-PHENYLPROPYLAMIDE

The present invention relates to isolated stereoisomeric forms of the compound (S)2-N(3- 0-(propan 2-ol)-l-propyl-4-hydroxybenzene)-3-phenylpropylamide. Specifically, the present invention relates to the use of (S)2-N(3-0-((S)propan 2-ol)-l-propyl-4- hydr

Substituted dodecahydrotriphenylenes, decahydro-1H-cyclopenta[1]phenanthrenes, decahydro-1H-pyrido[1,2-f]phenanthridines and decahydropyrrolo[1,2-f]phenanthridines as CNS agents

1,2,3,4,4a,4b,5,6,7,8,8a,12b-Dodecahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy or alkoxyalkyl)triphenylenes, 2,3,3a,3b,4,5,6,7,7a,11b-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)-1H-cyclopenta[1]phenanthrenes, 2,3,4,4a,4b,5,6,7,8,8a-decahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl)-1H-pyrido[1,2-f]phenanthridines, and 1,2,3,3a,3b,4,5,6,7,7a-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)pyrrolo[1,2-f]phenanthridines and derivatives are valuable as central nervous system active agents or as intermediates to compounds having such activity.

Substituted hexahydropyrrolo[1,2-a]-quinolines, hexahydro-1H-pyrido[1,2-a]-q

Tricyclic benzo fused compounds of the formula STR1 and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R1 is H or certain acyl groups; Q is CO2 R4, COR5, C(OR7)R5 R6, CN, CONR9 R10, CH2 NR9 R10, CH2 NHCOR11, CH2 NHSO2 R12, 5-tetrazolyl or when n is 1, Q and OR1 together form a lactone or certain reduced derivatives thereof; and Z is certain alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl groups, are valuable central nervous system active agents, methods for their use, pharmaceutical compositions containing them and certain intermediates therefor.

Stereospecific synthesis of 5-phenyl-2S-pentanol

5-Phenyl-2S-pentanol is synthesized stereospecifically from S ethyl lactate. The method provides easily purified 5-phenyl-2S-pentanol useful in the synthesis of central nervous system active (CNS) agents such as levonantradol.