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Usage

Uses

Used in Pharmaceutical Industry:
2-(ethylamino)isonicotinonitrile is utilized as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs. Its role in the production process is pivotal due to its ability to form complex organic molecules that can address various medical needs.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(ethylamino)isonicotinonitrile is employed as a reactant in the production of agrochemicals. Its chemical properties make it suitable for creating compounds that can be used in pest control and crop protection, thereby enhancing agricultural productivity.
Used in Organic Synthesis:
2-(ethylamino)isonicotinonitrile is used as a building block in organic synthesis for the preparation of complex organic molecules. Its structural attributes allow it to be a valuable component in the construction of a wide array of organic compounds.
Used in Heterocyclic Compounds Synthesis:
2-(ethylamino)isonicotinonitrile also serves as a crucial intermediate in the synthesis of various heterocyclic compounds. Heterocyclic chemistry is significant in many fields, including pharmaceuticals and materials science, making 2-(ethylamino)isonicotinonitrile an important precursor in these areas.
Used in Research and Development:
2-(ethylamino)isonicotinonitrile is applied in research and development settings for the exploration of new materials and drug candidates. Its potential in this domain is a testament to its versatility and the breadth of its applicability in scientific innovation.

Upstream product

• 33252-30-1 2-chloro-4-pyridinenitrile 
• 75-04-7 ethylamine 

Relevant academic research and scientific papers

Diarylthiazole: An antimycobacterial scaffold potentially targeting PrrB-PrrA two-component system

Diarylthiazole (DAT), a hit from diversity screening, was found to have potent antimycobacterial activity against Mycobacterium tuberculosis (Mtb). In a systematic medicinal chemistry exploration, we demonstrated chemical opportunities to optimize the potency and physicochemical properties. The effort led to more than 10 compounds with submicromolar MICs and desirable physicochemical properties. The potent antimycobacterial activity, in conjunction with low molecular weight, made the series an attractive lead (antibacterial ligand efficiency (ALE) >0.4). The series exhibited excellent bactericidal activity and was active against drug-sensitive and resistant Mtb. Mutational analysis showed that mutations in prrB impart resistance to DAT compounds but not to reference drugs tested. The sensor kinase PrrB belongs to the PrrBA two component system and is potentially the target for DAT. PrrBA is a conserved, essential regulatory mechanism in Mtb and has been shown to have a role in virulence and metabolic adaptation to stress. Hence, DATs provide an opportunity to understand a completely new target system for antimycobacterial drug discovery.

Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: A potent and orally bioavailable NCX inhibitor

Ca2+ overload in myocardial cells is responsible for arrhythmia. Sodium-calcium exchanger (NCX) inhibitors are more effective than sodium-hydrogen exchanger (NHE) inhibitors with regard to modulation of Ca 2+ overload, because NCX inhibitors can directly inhibit the influx of Ca2+ into cells. NCX is an attractive target for the treatment of heart failure and ischemia-reperfusion. We have designed and synthesized a series of N-(2-aminopyridin-4-ylmethyl)nicotinamide derivatives, based on compound 5. We have discovered a novel NCX inhibitor (23h) with an IC 50 value of 0.12 μM against reverse NCX. The inhibitory activities of our NCX inhibitors against cytochrome P450 were also evaluated. The effects on heart failure and the pharmacokinetic profile of compound 23h are discussed.

The synthesis of 2-amino-4-(4-imidazolyl)pyridines

A general synthetic scheme for the preparation of 2-amino-4-(4-imidazolyl)pyridines, potential histamine H2 antagonists, is described. The synthesis is based on the Neber rearrangement of 1-(4-pyridyl)-l-alkanone oxime O-tosylates to the appropriate α-aminoketones or α-aminoketals, which are then converted to the corresponding imidazoles. The reaction of Grignard reagents with 2-chloroisonicotinonitrile, as well as nucleophilic displacement of chloride by amines on 2-chloroisonicotinonitrile and derivatives, are discussed in relation to the preparation of the ketone intermediates.