871258-12-7

Basic information

• Product Name: DlinDMA
• CAS NO: 871258-12-7
• Molecular Weight: 616.068
• Mol File: 871258-12-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 647.8±55.0 °C(Predicted)
• Density: 0.879±0.06 g/cm3(Predicted)
• CAS DataBase Reference: DlinDMA(CAS DataBase Reference)
• NIST Chemistry Reference: DlinDMA(871258-12-7)
• EPA Substance Registry System: DlinDMA(871258-12-7)

Safety Data

• Hazardous Substances Data: 871258-12-7(Hazardous Substances Data)

Usage

General Description

DlinDMA, or N,N-dimethyl-3,5-dinitrobenzylamine, is a chemical compound used as a curing agent in the manufacturing of epoxy resins. Its primary function is to promote the cross-linking of the epoxy molecules, leading to improved strength, adhesion, and chemical resistance of the resin. DlinDMA is also a highly reactive compound and is known for its fast curing properties, making it a popular choice in the production of high performance coatings, adhesives, and composite materials. However, due to its potential health hazards and environmental impact, proper handling and disposal of DlinDMA is necessary to ensure safety and compliance with regulations.

Upstream product

• 623-57-4 3-(dimethylamino)-1,2-propanediol 
• 51154-39-3 (9Z,12Z)-octadeca-9,12-dienyl methanesulfonate 
• 56401-30-0 (9Z,12Z)-octadeca-9,12-dienyl tosylate 

Relevant articles and documents

Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles

We report a potent cationic lipid, SST-02 ((3-hydroxylpropyl)dilinoleylamine), which possesses a simple chemical structure and is synthesized just in one step. Cationic lipids are key components of siRNA-lipid nanoparticles (LNP), which may serve as potential therapeutic agents for various diseases. For a decade, chemists have given enhanced potency and new functions to cationic lipids along with structural complexity. In this study, we conducted a medicinal chemistry campaign pursuing chemical simplicity and found that even dilinoleylmethylamine (SST-01) and methylpalmitoleylamine could be used for the in vitro and in vivo siRNA delivery. Further optimization revealed that a hydroxyl group boosted potency, and SST-02 showed an ID50 of 0.02 mg/kg in the factor VII (FVII) model. Rats administered with 3 mg/kg of SST-02 LNP did not show changes in body weight, blood chemistry, or hematological parameters, while the AST level decreased at a dose of 5 mg/kg. The use of SST-02 avoids a lengthy synthetic route and may thus decrease the future cost of nucleic acid therapeutics.

LIPID ENCAPSULATING INTERFERING RNA

Rich tooling is provided for REST application development that integrates the exploration of a REST API, modeling of data types and the REST API, and the generation of artifacts using the modeled REST API and data types.

COMPOSITIONS AND METHODS FOR ENHANCING CELLULAR UPTAKE AND INTRACELLULAR DELIVERY OF LIPID PARTICLES

Compositions, methods and compounds useful for enhancing the uptake of a lipid particle b\ a cell are described In particular embodiments, the methods of the invention include contacting a cell with a lipid particle and a compound that binds a Na+/K+ ATPase to enhance uptake of the lipid particle b\ the cell Related compositions useful in practicing methods include lipid particles comprising a conjugated compound that enhances uptake of the lipid particles b\ the cell The methods and compositions are useful in delivering a therapeutic agent to a cell, e g for the treatment of a disease or disorder in a subject