87128-39-0

Upstream product

• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 100-46-9 benzylamine 
• 590-86-3 isovaleraldehyde 
• 100-39-0 benzyl bromide 
• 87128-37-8 1-benzyl-6-isobutyl-4-(4-methoxybenzyl)-2,5-piperazinedione 
• 100593-02-0 1-benzyl-6-(2-methylpropylidene)-piperazine-2,5-dione 
• 53736-79-1 (Z)-1-Acetyl-3-(2-methylpropylidene)piperazine-2,5-dione 
• 100592-98-1 1-acetyl-4-benzyl-3-(2-methylpropylidene)-piperazine-2,5-dione 
• 100-44-7 benzyl chloride 

Downstream Products

• 87128-38-9 3-allyl-1-benzyl-6-isobutyl-4-(4-methoxybenzyl)-2,5-piperazinedione 
• 87128-42-5 3-allyl-1-benzyl-6-isobutyl-2,5-piperazinedione 
• 87128-37-8 1-benzyl-6-isobutyl-4-(4-methoxybenzyl)-2,5-piperazinedione 

Relevant academic research and scientific papers

The universal Rink-isonitrile resin: Applications in Ugi reactions

The Rink-isonitrile resin provides a new universal platform for Ugi multi-component reactions. Applications were demonstrated by the traceless synthesis of diketopiperazines, benzodiazepines, and 5-substituted 1H-tetrazoles.

The solution phase synthesis of diketopiperazine libraries via the Ugi reaction: Novel application of Armstrong's convertible isonitrile.

This communication describes the generation of high-yielding solution phase diketopiperazine libraries via a '3-step, 1-pot' procedure, employing the Ugi multi-component reaction (MCR), followed by BOC deprotection and cyclization to diketopiperazine (DKP). Exploitation of Armstrong's convertible isonitrile in the Ugi reaction utilising an 'internal nucleophile' approach for diketopiperazine formation is presented.

Oxidative Removal of N-(4-Methoxybenzyl) Group on 2,5-Piperazinedinones with Cerium(IV) Diammonium Nitrate

It was shown that N-(4-methoxybenzyl) group on 2,5-piperazinediones can be oxidatively removed with cerium(IV) diammonium nitrate under mild conditions, and the oxidative removal was performed in some model compounds which have several functional groups.

OXIDATIVE REMOVAL OF N-(p-METHOXYBENZYL) GROUP ON DIKETOPIPERAZINE SKELETON WITH CERIC AMMONIUM NITRATE

N-(p-Methoxybenzyl) groups in some diketopiperazine derivatives were proved to be readily and efficiently removed with ceric ammonium nitrate in acetonitrile-water under mild conditions, where N-benzyl, methoxyl in the aminal structure, and isolated vinyl