88275-88-1Relevant articles and documents
An Oxidative Dearomatization Approach to Tetrodotoxin via a Masked ortho-Benzoquinone
Robins, Jacob G.,Johnson, Jeffrey S.
, p. 559 - 563 (2022/01/20)
Progress toward a stereoselective synthesis of tetrodotoxin (TTX) is presented. Oxidative dearomatization of a tetrasubstituted guaiacol arene yielded a masked ortho-benzoquinone that intercepted an acyl nitroso species generated in situ by the copper-cat
A Mild meta-Selective C–H Alkylation of Catechol Mono-Ethers
Vitaku, Edon,Njardarson, Jon T.
, p. 3679 - 3683 (2016/08/16)
Catechol mono-ethers are an important class of phenols. They are found in a number of pharmaceuticals, flavoring agents, perfumes, and are used for the preparation of numerous drugs. Herein, we report a mild meta-selective C–H alkylation of these phenols, which is enabled by a cascade of oxidative dearomatization – radical addition – rearomatization process. The method is compatible with reactive functional groups on the parent arenol, such as olefins and halides. Primary, secondary, and teriary alkyl groups can be used, the source of which is most commonly an alkylborane. This process is operationally simple, does not require heating and generally proceeds in good yields.
Synthesis of benzopyran prostaglandins, potent stable prostacyclin analogs, via an intramolecular mitsunobu reaction
Aristoff,Harrison,Huber
, p. 3955 - 3958 (2007/10/02)
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