871339-75-2

Upstream product

• 871339-74-1 1,1-dimethylethyl 4-{2-methyl-5-{[(phenylmethyl)oxy]carbonyl}-3-[(2-pyrrolidin-1-ylethyl)amino]phenyl}piperazine-1-carboxylate 
• 407-25-0 trifluoroacetic anhydride 
• 100-39-0 benzyl bromide 
• 67973-32-4 3,5-dibromo-4-methylbenzoic acid 
• 871339-73-0 1,1-dimethylethyl 4-(3-bromo-2-methyl-5-{[(phenylmethyl)oxy]carbonyl}phenyl)piperazine-1-carboxylate 
• 871339-72-9 phenylmethyl 3,5-dibromo-4-methylbenzoate 

Downstream Products

• 871464-71-0 5-bromo-2-methyl-3-piperazin-1-yl-N-(2-pyrrolidin-1-ylethyl)aniline 
• 871339-81-0 N-{5-bromo-2-methyl-3-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}-2,2,2-trifluoro-N-(2-pyrrolidin-1-ylethyl)acetamide 
• 871339-80-9 N-{5-amino-2-methyl-3-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}-2,2,2-trifluoro-N-(2-pyrrolidin-1-ylethyl)acetamide 
• 871339-77-4 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoyl fluoride 
• 871339-78-5 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoyl azide 
• 871339-79-6 1,1-dimethylethyl {4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}carbamate 
• 871339-76-3 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoic acid 

Relevant academic research and scientific papers

KINASE MODULATORS AND METHODS OF USE

The present invention relates to compounds of the Formula I and II wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.