87137-49-3

Upstream product

• 79-20-9 acetic acid methyl ester 
• 6278-91-7 4-(benzyloxy)-2-butanone 
• 154170-47-5 5-benzyloxy-3-methylpentane-1,3-diol 
• 154066-62-3 4-(2-Benzyloxy-ethyl)-2,2,4-trimethyl-[1,3]dioxane 
• 154066-61-2 1,3-O,O-isopropylidene-3-methylpentane-1,3,5-triol 
• 100-39-0 benzyl bromide 
• 7564-64-9 3-methyl-1,3,5-pentanetriol 

Relevant academic research and scientific papers

Chirality of the 3-hydroxy-3-methylglutaric acid moiety of fasciculic acid A, a calmodulin antagonist isolated from Naematoloma fasciculare

The chirality of the 3-hydroxy-3-methylglutaric acid (HMGA) moiety of fasciculic acid A (1), a calmodulin antagonist isolated from Naematoloma fasciculare, was established to be S by comparing the 1H-NMR spectrum of the L-alanylamide of HMGA de

Enantioselective Hydrolysis of 3-Hydroxy-3-methylalkanoic Acid Esters with Pig Liver Esterase

Pig liver esterase has been shown to stereoselectively hydrolyze the R enantiomer of several chiral 3-hydroxy-3-methylalkanoic acid esters of the form RC(Me)(OH)CH2COOR', where R = Et, CH2=CHCH2, Me(CH2)5, (MeO)2CHCH2, and PhCH2OCH2CH2 and R'= Me or Et.The unhydrolyzed ester and the reesterified carboxylic acid were analyzed for enantiomeric purity by NMR using the chiral shift reagent Eu(hfc)3.For the compounds studied, the S enantiomers consistently showed greater induced shifts.Products of the resolution are potential intermediates in the preparation of compactin analogues having defined stereochemistry at carbon-3.These analogues will be useful in testing the hypothesis that the hypocholesterolemic activity of compactin and its analogues resides in their ability to mimic the binding of mevaldic acid coenzyme A hemithioacetal to HMG-CoA reductase but not be reduced to mevalonate.