871570-97-7

Upstream product

• 141-32-2 acrylic acid n-butyl ester 
• 62303-05-3 2-iodo-N-(p-tolyl)benzamide 
• 609-67-6 2-Iodobenzoyl chloride 
• 582-78-5 N-(4-methylphenyl)benzamide 
• 88-67-5 2-Iodobenzoic acid 

Relevant academic research and scientific papers

Rh(III)-catalyzed tandem oxidative olefination-michael reactions between aryl carboxamides and alkenes

Rh(III)-catalyzed oxidative coupling reactions between benzamides or heteroaryl carboxamides and olefins have been developed. The vinylation product can further undergo a Michael reaction leading to γ-lactam in the case of electron-withdrawing olefins.

Palladium mediated synthesis of isoindolinones and isoquinolinones

The palladium-catalyzed reactions of 2-iodo-N-substituted benzamides 5-10 with acrylic esters 11-14 led to N-substituted-3-alkylisoindolinone esters 15-22 in good yields. The esters of isoindolinones 15-22 underwent hydrolysis reactions yielding the N-aryl-1,2,3,4-tetrahydro-1-oxoisoquinoline-3-carboxylic acid 26-31 in good yields.