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Usage

Uses

Used in Pharmaceutical and Biochemical Research:
Ethanone, 1-[4-(aminomethyl)phenyl](9CI) is utilized as a key intermediate in the synthesis of various pharmaceutical compounds and bioactive molecules. Its presence in the structure allows for the development of new drugs with potential therapeutic applications.
Used in Structure-Function Studies:
In the field of enzymology, Ethanone, 1-[4-(aminomethyl)phenyl](9CI) is employed in structure-function studies of substrate oxidation by bovine serum amine oxidase. This application aids researchers in understanding the enzyme's mechanism of action and its role in biological processes.
Used in Chemical Synthesis:
Ethanone, 1-[4-(aminomethyl)phenyl](9CI) serves as a versatile building block in organic synthesis, enabling the creation of a wide range of chemical compounds. Its reactivity and functional groups make it suitable for various synthetic routes, leading to the production of target molecules with specific properties and applications.
Used in Analytical Chemistry:
Ethanone, 1-[4-(aminomethyl)phenyl](9CI) can also be used in analytical chemistry as a reference material or standard for the development and validation of analytical methods. Its unique structure and properties make it a valuable tool for assessing the performance of chromatographic, spectroscopic, and other analytical techniques.

Upstream product

• 7441-43-2 4-ethylbenzylamine 
• 1443-80-7 4-cyanophenyl methyl ketone 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 91991-67-2 1-{4-[(6-Amino-5-nitro-pyridin-2-ylamino)-methyl]-phenyl}-ethanone 
• 1039454-77-7 N-(4-acetylbenzyl)benzamide 
• 1443-80-7 4-cyanophenyl methyl ketone 
• 1263183-81-8 N-1-(4-(((4-acetylbenzyl)imino)methyl)phenyl)ethan-1-one 
• 7441-43-2 4-ethylbenzylamine 

Relevant academic research and scientific papers

A cobalt phosphide catalyst for the hydrogenation of nitriles

The study of metal phosphide catalysts for organic synthesis is rare. We present, for the first time, a well-defined nano-cobalt phosphide (nano-Co2P) that can serve as a new class of catalysts for the hydrogenation of nitriles to primary amines. While earth-abundant metal catalysts for nitrile hydrogenation generally suffer from air-instability (pyrophoricity), low activity and the need for harsh reaction conditions, nano-Co2P shows both air-stability and remarkably high activity for the hydrogenation of valeronitrile with an excellent turnover number exceeding 58000, which is over 20- to 500-fold greater than that of those previously reported. Moreover, nano-Co2P efficiently promotes the hydrogenation of a wide range of nitriles, which include di- and tetra-nitriles, to the corresponding primary amines even under just 1 bar of H2 pressure, far milder than the conventional reaction conditions. Detailed spectroscopic studies reveal that the high performance of nano-Co2P is attributed to its air-stable metallic nature and the increase of the d-electron density of Co near the Fermi level by the phosphidation of Co, which thus leads to the accelerated activation of both nitrile and H2. Such a phosphidation provides a promising method for the design of an advanced catalyst with high activity and stability in highly efficient and environmentally benign hydrogenations. This journal is

Preparation of a magnetic mesoporous Fe3O4-Pd@TiO2 photocatalyst for the efficient selective reduction of aromatic cyanides

Herein, a hierarchical magnetic mesoporous microsphere was successfully prepared as a photocatalyst via a simple and reproducible route. Typically, Pd nanoparticles (NPs) were evenly dispersed on the surface of a magnetic Fe3O4 microsphere and then coated with a porous anatase-TiO2 shell to form Fe3O4-Pd@TiO2. The core-shell structure could efficiently suppress the conglomeration of Pd NPs during the calcination process at high temperatures as well as the shedding of Pd during the catalytic reaction process in the liquid phase. The as-prepared photocatalyst was characterized by TEM, XRD, XPS, VSM, and N2 adsorption-desorption. Fe3O4-Pd@TiO2 exhibits high photocatalytic activity for the selective reduction of aromatic cyanides to aromatic primary amines in an acidic aqueous solution. Moreover, this magnetic photocatalyst could be easily recovered from the reaction mixture by an external magnet and reused five times without significant reduction in its activity. The superior photocatalytic efficiency of the proposed photocatalyst may be attributed to its high charge separation efficiency and charge transfer rate, which are caused by the Schottky junction and large interface area. The results indicate that the strategy of coating the active noble metal sites with a mesoporous semiconductor shell has a significant potential for application in metal-semiconductor-based photocatalytic reactions.

Cobalt-Catalyzed and Lewis Acid-Assisted Nitrile Hydrogenation to Primary Amines: A Combined Effort

The selective hydrogenation of nitriles to primary amines using a bench-stable cobalt precatalyst under 4 atm of H2 is reported herein. The catalyst precursor was reduced in situ using NaHBEt3, and the resulting Lewis acid formed, BEt3, was found to be integral to the observed catalysis. Mechanistic insights gleaned from para-hydrogen induced polarization (PHIP) transfer NMR studies revealed that the pairwise hydrogenation of nitriles proceeded through a Co(I/III) redox process.

Remote C(sp3)-H Oxygenation of Protonated Aliphatic Amines with Potassium Persulfate

This letter describes the development of a method for selective remote C(sp3)-H oxygenation of protonated aliphatic amines using aqueous potassium persulfate. Protonation serves to deactivate the proximal C(sp3)-H bonds of the amine substrates and also renders the amines soluble in the aqueous medium. These reactions proceed under relatively mild conditions (within 2 h at 80 °C with amine as limiting reagent) and do not require a transition metal catalyst. This method is applicable to a variety of types of C(sp3)-H bonds, including 3°, 2°, and benzylic C-H sites in primary, secondary, and tertiary amine substrates.

One-pot primary aminomethylation of aryl and heteroaryl halides with sodium phthalimidomethyltrifluoroborate

A one-pot primary aminomethylation of aryl halides, triflates, mesylates, and tosylates via Suzuki-Miyaura cross-coupling reactions with sodium phthalimidomethyltrifluoroborate followed by deamidation with ethylenediamine is reported.