87172-18-7

Upstream product

• 487-68-3 mesytaldehyde 
• 98-86-2 acetophenone 
• 66057-05-4 (E)- and (Z)-2-bromo-1-phenylethylene acetate 
• 74636-46-7 C₈H₆LiO^(1-)*Li⁽¹⁺⁾ 
• 15724-86-4 E-2-chlorovinyl phenyl ketone 
• 108-67-8 1,3,5-trimethyl-benzene 

Downstream Products

• 1438279-07-2 (S)-3-(1H-indol-3-yl)-3-mesityl-1-phenylpropan-1-one 
• 95465-71-7 3-(2,4,6-trimethylphenyl)-1-phenylpropan-1-one 

Relevant academic research and scientific papers

Transition-Metal-Free Synthesis of Homo- and Hetero-1,2,4-Triaryl Benzenes by an Unexpected Base-Promoted Dearylative Pathway

An unprecedented approach for the synthesis of homo- and hetero-1,2,4-triaryl benzenes has been developed using a simple base-mediated reaction of either α-aryl cinnamyl alcohols or α,γ-di-aryl propanones. The salient feature of this strategy involves the sequential hydride transfer, regiospecific condensation, regiospecific dearylation, and aromatization under metal-free reaction conditions. The synthesis of unsymmetrically substituted triphenylenes by oxidative coupling of the synthesized 1,2,4-triaryl benzenes has also been demonstrated.

Synthesis and crystal structures of (E)-1-Phenyl-3-[(2,4,6-Trimethylphenyl) ]prop-2-En-1-One and (E)-1-Phenyl-3-[(4-Trifluoromethylphenyl)]prop-2-En-1-One

Two chalcone compounds, namely (E)-1-phenyl-3-[(2,4,6-trimethylphenyl)] prop-2-en- 1-one (1) and (E)-1-phenyl-3-[(4-trifluoromethylphenyl)]prop-2-en-1- one (2), have been synthesized and structurally characterized by elemental analysis, 1H NMR

Solution-phase parallel synthesis of substituted chalcones and their antiparasitary activity against Giardia lamblia

A library of 25-membered chalcones was prepared by parallel synthesis. Substituted acetophenones and benzaldehydes were condensed using the Claisen-Schmidt base-catalyzed aldol condensation. Several chalcones showed in vitro antiparasitic activity against Giardia lamblia. The highest activity observed for the IC50 values were 12.72, 15.05 and 15.31 μg/mL, respectively; these are potential leads for the development of antigiardial compounds.