871732-99-9Relevant academic research and scientific papers
Bisnucleophilic substitution as a synthetic tool for ready access to the piperidine alkaloids (+)-Connine, (+)-β-conhydrine, (+)-8-ethylnorlobelol, and (-)-halosaline
Raju, Galla,Anitha, Kadimi,Krishna, Palakodety Radha
, p. 937 - 941 (2015/04/27)
Herein we report the stereoselective total synthesis of (+)-connine, (+)-β-conhydrine, (+)-8-ethylnorlobelol, and (-)-halosaline via bisnucleophilic substitution with benzylamine as the key step.
Synthesis of the C1-C16 fragment of spirastrellolide A
Liu, Jia,Yang, Jin Haek,Ko, Changhong,Hsung, Richard P.
, p. 6121 - 6123 (2007/10/03)
Synthesis of the C1-C16 fragment of spirastrellolide A is described here featuring Sharpless asymmetric epoxidation, an acid promoted O-1,4-addition, and Mukaiyama 1,3-anti-aldol.
The total synthesis and reassignment of stereochemistry of dragonamide
Chen, Hongliang,Feng, Yaqing,Xu, Zhengshuang,Ye, Tao
, p. 11132 - 11140 (2007/10/03)
The first total synthesis of dragonamide is reported. The synthesis has led to a reassignment of the configuration at the stereogenic centre on the alkyne-bearing fragment of the molecule.
1,8-Diazabicyclo[5.4.0]undec-7-ene: A remarkable base in the debromination of 4- or 5-substituted N-benzyl α-bromo-α-p- toluenesulfonylglutarimide
Chang, Meng-Yang,Lin, John Yi-Chung,Chen, Shui-Tein,Chang, Nein-Chen
, p. 1015 - 1024 (2007/10/03)
Debromination of N-benzyl 4- or 5-substituted α-bromo-α-p- toluenesulfonylglutarimides is achieved with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to give the N-benzyl 4- or 5-substituted α-p- toluenesulfonylglutarimides. The DBU/THF system is applied to a new methodology for the synthesis of bicyclic glutarimide skeleton in moderate yields.
