871840-22-1

Upstream product

• 108-30-5 succinic acid anhydride 
• 708984-65-0 7-methyl-3-(3-trifluoromethylphenyl)-5,6,7,8-tetrahydrocinnoline-5-ol 
• 708984-57-0 7-methyl-3-(3-trifluoromethylphenyl)-7,8-dihydro-6H-cinnoline-5-one 
• 708984-56-9 7-methyl-3-(3-trifluoromethylphenyl)-4,6,7,8-tetrahydro-1H-cinnoline-5-one 
• 708984-73-0 3-hydroxy-5-methyl-2-[2-oxo-2-(3-trifluoromethylphenyl)-ethyl]-cyclohex-2-enone 
• 349-76-8 3'-(trifluoromethyl)acetophenone 
• 2003-10-3 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone 

Relevant academic research and scientific papers

NOVEL 3-PHENYLTETRAHYDROCINNOLIN-5-OL DERIVATIVE AND MEDICINAL USE THEREOF

A 3-phenyltetrahydrocinnolin-5-ol derivative represented by the following general formula (1) (wherein Z represents 2-carboxyethyl, 3-dimethylaminopropyl etc.; X represents trifluoromethyl etc.; X' represents hydrogen, etc.; and Y anti Y' each represents methyl, hydrogen, etc.), a physiologically acceptable salt thereof, or a prodrug of either. They have cytostatic activity against tumor cells and hence are effective as an antitumor agent.

NOVEL 3-PHENYLTETRAHYDROCINNOLIN-5-OL DERIVATIVE AND MEDICINAL USE THEREOF

A 3-phenyltetrahydrocinnolin-5-ol derivative represented by the following general formula (1) (wherein Z represents 2-carboxyethyl, 3-dimethylaminopropyl, etc.; X represents trifluoromethyl, etc.; X' represents hydrogen, etc.; and Y and Y' each represents