871880-36-3Relevant academic research and scientific papers
Iron(III)-Mediated Nucleophilic Halogenation of Phenols Using an Amido Directing Group
Guo, Dou,Liu, Yibo,Lu, Dongbiao,Lu, Yufan,Meng, Wei,Wan, Congcong,Wang, Hongling,Yang, Hongxiang,Yuan, Ye,Zhang, Xiang
, (2022/05/20)
A regioselective and nucleophilic halogenation of electron-rich amidophenols was realized in the presence of Fe(III) reagents and amido-directing groups. Halides could be sequentially introduced to specific positions to form mono-, di- and mixed di- halogenated amidophenols. Furthermore, this protocol provides new methods for the syntheses of IKK2 inhibitor (IMD-0354), muscle relaxant (Chlorzoxazone) and related derivatives.
