87192-03-8Relevant academic research and scientific papers
Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis
Chen, Tian,Benmohamed, Radhia,Arvanites, Anthony C.,Ranaivo, Hantamalala Ralay,Morimoto, Richard I.,Ferrante, Robert J.,Watterson, D. Martin,Kirsch, Donald R.,Silverman, Richard B.
experimental part, p. 613 - 622 (2011/03/17)
Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease currently without a cure. Mutations in copper/zinc superoxide dismutase 1 (SOD1) have been implicated in the pathophysiology of this disease. Using a high-throughput screening assa
TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
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Page/Page column 110, (2010/07/10)
The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
Ring Construction Using 3-(Arylmethylene)-2,4(3H,5H)-furandione: Synthesis of Pyrazolones and Furobenzothiazepinones
Grob Schmidt, Diane,Zimmer, Hans
, p. 4367 - 4370 (2007/10/02)
The ring transformation of 3-(arylmethylene)-2,4(3H,5H)-furandiones (2) into the corresponding pyrazolones (3) is described.The conversion with selected hydrazines proceeds regioselectively to form a uniquely substituted pyrazolone system (3) as the major
