871927-92-3

Basic information

• Product Name: 2-[3-benzyloxycarbonyl-2-(3-benzyloxycarbonyl-2-{6-[3-(2-phenylethynyl-cyclohex-1-enylethynyl)-phenyl]-hex-5-ynoylamino}-propionylamino)propionylamino]-succinic acid dimethyl ester
• Synonyms: 2-[3-benzyloxycarbonyl-2-(3-benzyloxycarbonyl-2-{6-[3-(2-phenylethynyl-cyclohex-1-enylethynyl)-phenyl]-hex-5-ynoylamino}-propionylamino)propionylamino]-succinic acid dimethyl ester
• CAS NO: 871927-92-3
• Molecular Weight: 946.066
• Mol File: 871927-92-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[3-benzyloxycarbonyl-2-(3-benzyloxycarbonyl-2-{6-[3-(2-phenylethynyl-cyclohex-1-enylethynyl)-phenyl]-hex-5-ynoylamino}-propionylamino)propionylamino]-succinic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-benzyloxycarbonyl-2-(3-benzyloxycarbonyl-2-{6-[3-(2-phenylethynyl-cyclohex-1-enylethynyl)-phenyl]-hex-5-ynoylamino}-propionylamino)propionylamino]-succinic acid dimethyl ester(871927-92-3)
• EPA Substance Registry System: 2-[3-benzyloxycarbonyl-2-(3-benzyloxycarbonyl-2-{6-[3-(2-phenylethynyl-cyclohex-1-enylethynyl)-phenyl]-hex-5-ynoylamino}-propionylamino)propionylamino]-succinic acid dimethyl ester(871927-92-3)

Safety Data

• Hazardous Substances Data: 871927-92-3(Hazardous Substances Data)

Upstream product

• 871927-89-8 L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester 
• 303142-43-0 6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoic acid 
• 871927-80-9 methyl 6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoate 
• 303142-37-2 1-phenyl-10-(1,1,1-triisopropylsilyl)-1,9-decadiyne-3,8-diol 
• 303142-38-3 (3,8-dibromo-10-phenyl-1,9-decadiynyl)(triisopropyl)silane 
• 303142-39-4 triisopropyl-2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynylsilane 
• 303142-40-7 1-(1-ethynyl)-2-(2-phenyl-1-ethynyl)-1-cyclohexene 
• 303142-41-8 methyl 6-(3-iodophenyl)-5-hexynoate 
• 871927-90-1 α-L-aspartyl β-benzyl ester L-aspartic acid dimethyl ester 
• 77758-51-1 methyl hex-5-ynoate 
• 871927-91-2 N-tert-butoxycarbonyl-L-aspartyl-(β-benzyl ester)-L-aspartyl-(β-benzyl ester)-L-aspartic acid dimethyl ester 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 626-00-6 1,3-Diiodobenzene 

Relevant articles and documents

Synthesis and protein degradation capacity of photoactivated enediynes

The viability of proteins as targets of thermally and photoactivated enediynes has been confirmed at the molecular level. Model studies using a labeled substrate confirmed the efficacy of atom transfer from diyl radicals produced from enediynes to form captodatively stabilized carbon centered aminoacyl radicals, which then undergo either fragmentation or dimerization. To exploit this finding, a family of enediynes was developed using an intramolecular coupling strategy. Derivatives were prepared and used to target specific proteins, showing good correlation between affinity and photoinduced protein degrading activity. The findings have potential applications in the design of artificial chemical proteases and add to our understanding of the mechanism of action of the clinically important enediyne antitumor antibiotics.