87200-65-5Relevant academic research and scientific papers
Cobalt-Catalyzed Regioselective Ortho C(sp2)-H Bond Nitration of Aromatics through Proton-Coupled Electron Transfer Assistance
Nageswar Rao, Desaboini,Rasheed, Sk.,Raina, Gaurav,Ahmed, Qazi Naveed,Jaladanki, Chaitanya Kumar,Bharatam, Prasad V.,Das, Parthasarathi
, p. 7234 - 7244 (2017/07/26)
A cobalt-catalyzed proton-coupled electron transfer (PCET) mediated regioselective ortho-specific nitration of aromatic C(sp2)-H bonds using chelation-assisted removable vicinal diamine directing groups was developed. The reaction proceeded under mild conditions in the presence of Co(OAc)2·4H2O as the catalyst with AgNO2 utilized as the nitro source as well as terminal oxidant in the presence of O2 as an external oxidant. No external base or additives were required for this process. Controlled experiments and mechanistic investigations with DFT calculations revealed that the reaction proceeds through a PCET promoted nitro functional group transfer pathway. Moreover, the produced compounds are valuable and pharmaceutically quite relevant.
Synthesis of 2-Arylaminobenzothiazoles and Aryl Isothiocyanates as Antitubercular Agents
Pande, Anil,Lokhande, S. R.,Patel, Madhuben R.,Khadse, B. G.
, p. 311 - 312 (2007/10/02)
A series of 2-arylaminobenzothiazoles (II) and aryl isothiocyanates (I) bearing a nitro group in the aryl moiety have been synthesized and screened against M. tuberculosis (H37Rv) in vitro.Most of the isothiocyanate derivatives (I) show antitub
