87204-00-0

Upstream product

• 23886-71-7 4-methoxy-4'-methylbenzophenone 
• 106-38-7 para-bromotoluene 
• 123-11-5 4-methoxy-benzaldehyde 
• 874-60-2 4-methyl-benzoyl chloride 
• 100-66-3 methoxybenzene 

Downstream Products

• 127193-49-1 diethyl 4-(4-methoxybenzoyl)benzylphosphonate 
• 898776-01-7 (4-methoxyphenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]methanone 
• 183165-43-7 1-[4-(4-Methoxybenzoyl)benzyl]-2,3,5-trimethyl-1H-pyrrolo [2,3-d]pyridazin-4(5H)-one 
• 1147092-71-4 {4-[(benzylmethylamino)methyl]phenyl}-(4-methoxyphenyl)methanone 
• 69677-70-9 C₂₁H₁₈O₂ 
• 1428527-58-5 diethyl 4-((hydroxyimino)(4-methoxyphenyl)methyl)benzylphosphonate 
• 1428527-59-6 diethyl 4-(amino(4-methoxyphenyl)methyl)benzylphosphonate 
• 1428527-60-9 diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonate 
• 1428527-61-0 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonic acid 
• 1445534-11-1 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)benzylphosphonic acid 

Relevant academic research and scientific papers

Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing

The inhibition of steroidogenic cytochrome P450 enzymes has been shown to play a central role in the management of life-threatening diseases such as cancer, and indeed potent inhibitors of CYP19 (aromatase) and CYP17 (17α hydroxylase/17,20 lyase) are curr

SUBSTITUTED PYRIMIDINES

Disclosed are substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

SUBSTITUTED PYRIMIDINES

The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors

Starting from a structure-based drug design, new acetylcholinesterase inhibitors were designed and synthesized as analogues of donepezil. The compounds were composed by an aromatic function and a tertiary amino moiety connected by a suitable spacer. In pa

ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE

Antimalarial agents having a novel pharmacophore of formula (I) are herein described. These polycyclic compounds are able to inhibit chloroquine-sensitive and chloroquine-resistant strains ofPlasmodium falciparum (Pf). Furthermore, the synthesis of these compounds involves few steps from commercial products with low cost of production.Λa présente invention concerne des agents antimalariaux comportant un nouveau pharmacophore de formule (I). Ces composés polycycliques sont susceptibles d''inhiber les souches sensibles à la chloroquine et résistantes à la chloroquine de Plasmodium falciparum (Pf). En outre, la synthèse de ces composés est peu onéreuse et implique peu d''étapes à partir des produits commerciaux.

Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: Exploring an innovative pharmacophore

Identification of new molecular scaffolds structurally unrelated to known antimalarials may represent a valid strategy to overcome resistance of P. falciparum (Pf) to currently available drugs. We describe herein the investigation of a new polycyclic phar

Photochemical Reaction of phosphonic Acids. Application to a Photo-degradable Surfactant

Upon UV-irradiation, the C-P bonds of methylphosphonic acids were cleaved in water (pH 12) to give 4-alkoxyphenyl p-tolyl ketones and orthophosphate in high efficiency.It was demonstrated that the acids can be used as photo-degradable surfactants.