872181-59-4

Basic information

• Product Name: 1-(3,5-DIFLUOROPHENYL)ETHANOL
• Synonyms: 3,5-DIFLUOROPHENYLMETHYLCARBINOL;1-(3,5-DIFLUOROPHENYL)ETHAN-1-OL;1-(3,5-DIFLUOROPHENYL)ETHANOL;(3,5-Difluorophenyl)methylcarbinol, 1-(3,5-Difluorophenyl)ethan-1-ol;3,5-Difluoro-alpha-methylbenzyl alcohol 97%;3,5-Difluoro-alpha-methylbenzylalcohol97%
• CAS NO: 872181-59-4
• Molecular Formula: C₈H₈F₂O
• Molecular Weight: 158.15
• Mol File: 872181-59-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(3,5-DIFLUOROPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,5-DIFLUOROPHENYL)ETHANOL(872181-59-4)
• EPA Substance Registry System: 1-(3,5-DIFLUOROPHENYL)ETHANOL(872181-59-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 872181-59-4(Hazardous Substances Data)

Usage

General Description

1-(3,5-Difluorophenyl)ethanol is a chemical compound with the molecular formula C8H8F2O. It is a colorless liquid with a molecular weight of 158.15 g/mol. 1-(3,5-DIFLUOROPHENYL)ETHANOL is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various drug molecules. It has also been studied for its potential antimicrobial and antifungal properties. Additionally, 1-(3,5-Difluorophenyl)ethanol has been used in research as a starting material for the preparation of other organic compounds. It is important to handle this chemical with care, as it may pose health hazards if not used properly.

Upstream product

• 117358-52-8 1-ethyl-3,5-difluorobenzene 
• 123577-99-1 3′,5′-difluoroacetophenone 
• 32085-88-4 3,5-difluorobenzaldehyde 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 872181-60-7 2-fluoro-6-[1-(3,5-diflurophenyl)-ethoxy]-benzonitrile 
• 321318-29-0 (R)-1-(3,5-difluorophenyl)ethan-1-amine 
• 1620014-24-5 N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide 
• 1620014-27-8 4-[(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-(trifluoromethyl)piperidin-1-yl]-3-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate 
• 1620013-79-7 N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide 
• 1620013-80-0 tert-butyl ((3R,4R,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-2,3-dihydrofuro[2,3-b]pyridin-4-yl}-5-methylpiperidin-3-yl)carbamate 
• 1355011-40-3 6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxylic acid 
• 1355011-39-0 methyl 6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxylate 
• 1063733-77-6 2-(3,5-difluorophenoxy)propan-2-ol 
• 123577-99-1 3′,5′-difluoroacetophenone 
• 1620013-87-7 N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide 
• 1620013-89-9 tert-butyl ((3S,5R)-1-{3-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl}-5-methylpiperidin-3-yl)carbamate 
• 1620013-88-8 4-{(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-methylpiperidin-1-yl}-3-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate 
• 1586045-19-3 1-(3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol 

Relevant articles and documents

Chromoselective Photocatalysis Enables Stereocomplementary Biocatalytic Pathways**

Controlling the selectivity of a chemical reaction with external stimuli is common in thermal processes, but rare in visible-light photocatalysis. Here we show that the redox potential of a carbon nitride photocatalyst (CN-OA-m) can be tuned by changing the irradiation wavelength to generate electron holes with different oxidation potentials. This tuning was the key to realizing photo-chemo-enzymatic cascades that give either the (S)- or the (R)-enantiomer of phenylethanol. In combination with an unspecific peroxygenase from Agrocybe aegerita, green light irradiation of CN-OA-m led to the enantioselective hydroxylation of ethylbenzene to (R)-1-phenylethanol (99 % ee). In contrast, blue light irradiation triggered the photocatalytic oxidation of ethylbenzene to acetophenone, which in turn was enantioselectively reduced with an alcohol dehydrogenase from Rhodococcus ruber to form (S)-1-phenylethanol (93 % ee).

Enantioselective Bioamination of Aromatic Alkanes Using Ammonia: A Multienzymatic Cascade Approach

Chiral amines are common drug building blocks and important active pharmaceutical ingredients. Preparing these functionalized compounds from simple materials, such as alkanes, is of great interest. We recently developed an artificial bioamination cascade for the C?H amination of cyclic alkanes by combining P450 monooxygenase, alcohol dehydrogenase, and amine dehydrogenase. Herein, this system has been extended to the synthesis of chiral aromatic amines. In the first hydroxylation step, process optimization increased the conversion to 77 %. Two stereoselectively complementary alcohol dehydrogenases and an amine dehydrogenase were selected for the bioconversion of aromatic hydrocarbons to amines. The amination reaction was optimized with respect to cofactor addition and enzyme dosage. Isopropanol was added to decrease ketone intermediate accumulation in the amination step, which further enhanced the overall conversion. This cascade system converted a panel of hydrocarbon substrates into the corresponding amines with excellent optical purity (>99 % ee) and moderate conversion ratios (13–53 %).

THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS

The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.